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Apolipoprotein E/ApoE Antibody

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-65261
    • Availability
      Product Discontinued

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Apolipoprotein E/ApoE Antibody Summary

Immunogen
Human Apolipoprotein E
Specificity
NB100-65261 recognizes Apolipoprotein E (APOE). APOE is important in the metabolism of lipoproteins and in cardiovascular disease. More recently it has been linked to Alzheimer's disease. It is thought that APOE enhances the proteolytic breakdown of the beta-amyloid peptide, a major component of amyloid plaques. NB100-65261 has minimal cross reactivity with Apo A-1, A-2, B, C-2, C-3 and serum proteins.
Clonality
Polyclonal
Host
Goat
Gene
APOE
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • ELISA
Control
Apolipoprotein E/ApoE Overexpression Lysate

Reactivity Notes

Reacts with Rabbit and Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.09% Sodium Azide
Concentration
5.0 mg/ml
Purity
Protein G purified

Alternate Names for Apolipoprotein E/ApoE Antibody

  • APOE
  • Apo-E
  • Apolipoprotein E
  • apolipoprotein E3
  • late onset)
  • MGC1571

Background

Apolipoprotein E is essential for the normal catabolism of triglyceride rich lipoprotein constituents. The apolipoprotein E gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in Apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Mutations in the APOE gene confer susceptibility to Alzheimer's disease by affecting amyloid-beta deposition.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Control Lysate(s)

Apolipoprotein E/ApoE Overexpression Lysate

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol APOE
Entrez