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ApoE Antibody (NB100-65261)

ApoE Antibody

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ApoE Antibody Summary:
Species:Hu, Rb
Applications:ELISA
Clonality:Polyclonal
Gene:APOE
Purity:Protein G purified
Host:Goat
Specificity:NB100-65261 recognizes Apolipoprotein E (APOE). APOE is important in the metabolism of lipoproteins and in cardiovascular disease. More recently it has been linked to Alzheimer's disease. It is thought that APOE enhances the proteolytic breakdown of the beta-amyloid peptide, a major component of amyloid plaques. NB100-65261 has minimal cross reactivity with Apo A-1, A-2, B, C-2, C-3 and serum proteins.
Publications:Antibody has at least 2 Background References.
Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur.
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ApoE Antibody Details:
Isotype:IgG
Immunogen:Human Apolipoprotein E
Species Reactivity:

Reacts with Rabbit and Human.

Applications:
Uses:ELISA
Dilutions:ELISA 1:100 - 1:1000
Unit Size:1.0 ml
Concentration:5.0 mg/ml
Positive Controls:1 Positive Controls
Packaging:
Storage:Store at 4 °C short term. Aliquot and store at -20 °C long term. Avoid freeze-thaw cycles.
Buffer:Phosphate buffered saline, pH 7.2
Preservative:0.09% Sodium Azide
Limitations:This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.
Gene Symbol: APOE
Entrez348 (Human)
 
Background:

Apolipoprotein E is essential for the normal catabolism of triglyceride rich lipoprotein constituents. The apolipoprotein E gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in Apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Mutations in the APOE gene confer susceptibility to Alzheimer's disease by affecting amyloid-beta deposition.
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Publications (2)

ApoE Antibody Background References:

  1. Zhang, W. (1996) Apolipoprotein E produced by human monocyte-derived macrophages mediates cholesterol efflux that occurs in the absence of added cholesterol acceptors. J Biol. Chem. 271: 28641-28646.
  2. Gaynor, P. M.et al. (1996) Accumulation of HDL Apolipoproteins accompanies abnormal cholesterol accumulation in Schnyders corneal dystrophy. Arterioscler. Thromb. Vasc. Biol. 16: 992-999.
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