ALK Antibody (M-801-100)
ALK Antibody (4F6)
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Distributor Data...
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anti-ALK tyrosine kinase receptor antibody, anti-CD 246 antibody, anti-CD 246, anti-Anaplastic lymphoma kinase p80 antibody, anti-Anaplastic lymphoma kinase antibody, anti-Anaplastic lymphoma kinase, anti-ALK tyrosine kinase receptor precursor antibody, anti-ALK tyrosine kinase receptor precursor, anti-ALK tyrosine kinase receptor, anti-ALK antibody |
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ALK Antibody (4F6) Summary: | | Gene: | ALK |
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| Purity: | Protein G purified |
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| Host: | Mouse |
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| | Specificity: | The specificity of this antibody has been confirmed by WB detection of the partial recombinant ALK tyrosine kinase receptor protein with the GST tag. |
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| | Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur. |
View Additional ALK Products ALK Antibody (4F6) Details: | Clone: | 4F6 |
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| Isotype: | IgG |
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| Immunogen: | A partial recombinant protein of human ALK (amino acids 251 to 351) with a GST tag. |
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| Uses: | This antibody is useful in Western Blot and ELISA. |
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| Dilutions: | ELISA, Western Blot |
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| Unit Size: | 0.1 mg |
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| Concentration: | Lyoph |
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Notes: Reconstitute in 0.1 ml of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20C for higher stability or at 4C with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Packaging: | Storage: | Store at 4 °C short term. Aliquot and store at -20 °C long term. Avoid freeze-thaw cycles. |
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| Buffer: | lyophilized - in phosphate buffered saline, pH7.2, 150mM NaCl. |
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| Preservative: | No Preservative |
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| Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. |
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Background: Anaplastic lymphoma kinase (ALK) was originally discovered as a NPM (Nucleophosmin)-ALK fusion protein. ALK and LTK (leukocyte tyrosine kinase) are receptor tyrosine kinases similar to the insulin receptor subfamily of kinases. LTK is found in murine B Lymphocyte precursors and in forebrain neurons. ALK is usually found in the nervous system. A truncated form of ALK occurs in many non Hodgkin's lymphomas.
The ALK gene is on chromosome 2. Upon translocation between chromosome 2 and chromosome 5 [t(2;5}], the ALK gene fuses with the NPM gene. NPM, also known as B23, is an ubiquitous nucleolar phosphoprotein involved in the transport of pre ribosomal components between the nucleolus and the cytoplasm. The chimeric product (NPM ALK) resulting from t(2;5) translocation is a protein of 80kDa with the N terminal portion of NPM linked to the complete intracellular portion of ALK. Karpas 299 and SUDHL1 lymphoid cell lines strongly express NPM ALK.
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Images (1) Reviews (0) Related Products (4) Exploring ALK
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Working with ALK
ALK Antibody (4F6) Images (1) WB: ALK Antibody [M-801-100] - Monoclonal antibody to human ALK tyrosine kinase receptor [4F6], M-801-100, detects a band of 36.74kDa when used for WB detection against the antigen. Note the GST tag alone has a molecular weight of 26 KDa. |
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Jump to: Primary Antibodies, Secondary Antibodies
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Related ProductsPrimary Antibodies (2)Secondary Antibodies| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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| Mouse IgG Antibody [Biotin] | NB720-B | Mu | ELISA, IHC-P, WB | | | | | | Mouse IgG Antibody [HRP] | NB720-H | Mu | ELISA, ICC, IHC-P, WB | | | | | | Mouse IgG Antibody [Alkaline Phosphatase] | NB720-AP | Mu | ELISA, ICC, IHC-P, WB | | | | | | Mouse IgG Antibody [FITC] | NB720-F | Mu | ICC, IHC-P | | (2) | | | | Mouse IgG Antibody | NB120-7056 | Bv(-), Ch(-), Eq(-), Gp(-), Gt(-), Ha(-), Hu(-), Mu, Rb(-), Rt(-), Sh(-) | ELISA, IHC-P, IP, WB | | | | | | See All » |
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