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Thyroglobulin Antibody (2H11)

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Product Details

Summary
Product Discontinued
View other related Thyroglobulin Primary Antibodies

Order Details


    • Catalog Number
      NB500-571
    • Availability
      Product Discontinued

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Thyroglobulin Antibody (2H11) Summary

Immunogen
thyroid follicular cells (Human)
Specificity
NB500-571 recognises antigen thyroglobulin (TG).
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
TG
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:80 - 1:100
Application Notes
Immunohistochemistry - Paraffin Recommend 1 hour at room temperature. Perform heat mediated antigen retrieval via the microwave method before commencing with IHC staining protocol, by using 0.01M citrate buffer, pH 6.

Reactivity Notes

Reacts with Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Phosphate buffered saline (PBS), pH 7.4
Preservative
15mM Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein A purified

Alternate Names for Thyroglobulin Antibody (2H11)

  • AITD3
  • AITD3TGN
  • cog
  • TDH3
  • Tg
  • TGN
  • Thyroglobulin

Background

Thyroglobulin is the glycoprotein precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is obtained from the thyroid gland and exhibits the general properties of the globulins. The human thyroglobulin (hTG) is a high molecular weight glycoprotein (605 kDa) found in the thyroid follicular cells. It plays a central role in the uptake, incorporation, and regulated biosynthesis of thyroid hormones, T4 and T3. Thyroid disorders are, in large part, due to autoimmune origin, and anti thyroglobulin autoantibodies were the first factor to be discovered. Anti hTG is found in all thyroid autoimmune diseases (Hashimoto's thyroiditis, Graves diseases), with the highest level observed in Hashimoto's thyroiditis. Anti hTG is also characteristic of thyroid cancer, and its determination can be used for the follow up of cancer patients.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Research Areas for Thyroglobulin Antibody (NB500-571)

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Blogs on Thyroglobulin.

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TTF1 / NKX2.1 - An essential regulator of lung development with implications in cancer diagnostics
Thyroid transcription factor 1 (TTF-1), also known as NKX2.1, is a conserved master regulatory transcription factor involved in the development of the lung, brain, and thyroid (1). In the lung TTF-1 positively regulates the expression of several lu...  Read full blog post.

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Bioinformatics

Gene Symbol TG
Entrez