Home » Integrin beta 2/CD18 » Integrin beta 2/CD18 Antibodies » Integrin beta 2/CD18 Antibody (M18/2) [DyLight 488]

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Integrin beta 2/CD18 Antibody (M18/2) [DyLight 488]

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Product Details

Summary
Product Discontinued
View other related Integrin beta 2/CD18 Primary Antibodies

Order Details


    • Catalog Number
      NB100-77379G
    • Availability
      Product Discontinued

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Integrin beta 2/CD18 Antibody (M18/2) [DyLight 488] Summary

Immunogen
Mouse CTL glycoprotein
Specificity
CD18 (M18/2)
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Rat
Gene
ITGB2
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Western Blot

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Integrin beta 2/CD18 Antibody (M18/2) [DyLight 488]

  • 959 beta subunit precursor)10
  • CD18 antigen
  • CD18
  • CD18beta 2
  • cell surface adhesion glycoprotein (LFA-1
  • CR3
  • Integrin beta 2
  • integrin beta-2
  • integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1;macrophage antigen 1 (mac-1) beta subunit)
  • integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
  • ITGB2
  • LAD
  • LCAMB
  • leukocyte cell adhesion molecule CD18
  • leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C
  • LFA-1 beta
  • LFA-1
  • MAC-1 beta
  • MF17
  • MFI7
  • P150
  • p150,95 beta

Background

CD18 is a 95 kD protein, also known as integrin beta2 subunit. It is expressed on all leukocytes. CD18, in association with integrin alpha chain CD11a, CD11b, and CD11c forms LFA-1, Mac-1, and alphaX beta2, respectively, and plays an important role in leukocytes adhesion. The CD18 integrin complexes bind ICAM-1 (CD54), ICAM-2 (CD102), ICAM-3 (CD50), iC3b, and fibrinogen. The M18/2 antibody is able to block tumor cell metastasis and enhance cell adhesion.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Research Areas for Integrin beta 2/CD18 Antibody (NB100-77379G)

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Blogs on Integrin beta 2/CD18.

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CD11b/CD18 and Neutrophil-Epithelial Interactions as Targets for Anti-Inflammatory Therapies
The beta-2 integrins, a family of four cell surface transmembrane glycoproteins expressed only on leukocytes, include CD11a/CD18, CD11b/CD18, CD11c/CD18, and CD11d/CD18. They consist of a common beta subunit (CD18) and homologous alpha subunits (CD11a...  Read full blog post.

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Bioinformatics

Gene Symbol ITGB2