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CD21 Antibody (Bu32)

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Product Details

Summary
Product Discontinued
View other related CD21 Primary Antibodies

Order Details


    • Catalog Number
      NB100-64361
    • Availability
      Product Discontinued

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CD21 Antibody (Bu32) Summary

Immunogen
Made to Human CD21
Marker
Histiocytic Marker
Specificity
NB100-64361 recognizes human CD21, a 145kD cell surface glycoprotein expressed by mature B lymphocytes, follicular dendritic cells, subsets of normal thymocytes and subsets of T cells. The CD21 molecule acts as a receptor for complement components C3d, C3dg and iC3b, as well as for Epstein Barr Virus. CD21 is part of the signalling complex that is linked to CD19, CD81 and phosphatidylinositol-3-kinase.The Bu32 antibody is reported to significantly inhibit the binding of CD21 to CD23.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
CR2
Purity
Tissue culture supernatant
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Applications/Dilutions

Dilutions
  • Flow Cytometry 1:50-1:200
  • Immunoprecipitation 1:10-1:500

Reactivity Notes

Reacts with Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
0.09% Sodium Azide
Purity
Tissue culture supernatant

Alternate Names for CD21 Antibody (Bu32)

  • C3DR
  • C3DRSLEB9
  • CD21 antigen
  • CD21
  • Complement C3d receptor
  • complement component (3d/Epstein Barr virus) receptor 2
  • complement receptor type 2
  • CR2
  • EBV receptor
  • Epstein-Barr virus receptor

Background

CD21 also known as complement receptor 2 (CR2), C3d receptor or EBV receptor is a 140 kDa protein. CD21 is a glycosylated type I transmembrane protein consisting of an extracellular face of a series of 15 or 16 CCP domains. CD21 is the receptor for complement components C3d and iC3b as well as the Epstein-Barr virus (EBV) glycoprotein gp350/220. The soluble CD21 (sCD21) was shown to efficiently trigger CD23 signaling pathways in human monocytes. By inducing release of proinflammatory cytokines and upregulating expression of molecules involved in antigen presentation, sCD21 modulates critical monocyte functions that may be relevant to allergic and inflammatory disorders.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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CD21 Antibody
(Bu32)
NB100-64361
CD21 Antibody (Bu32)
Species: Hu
Applications: Flow, IP

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Secondary Antibodies

 

Isotype Controls

Additional CD21 Products

Research Areas for CD21 Antibody (NB100-64361)

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Blogs on CD21.

Check out the latest blog posts on CD21.
How To Identify B Cell Subsets Using Flow Cytometry
By Victoria OsinskiUsing Flow Cytometry to Identify B Cell SubsetsIdentifying cellular subsets by flow cytometry requires careful and thorough planning in order to ensure the correct subset of cells are identified...  Read full blog post.
CD19: An Undoubted Biomarker for B Cells
CD19 is a cell surface protein member of the large immunoglobulin superfamily that complexes with CD21, CD81, and CD225 in the membrane of mature B-cells. A major function of CD19 is to assemble with the antigen receptor of B-lymphocytes to decrease t...  Read full blog post.

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Bioinformatics

Gene Symbol CR2
Entrez
Uniprot