ZAK Products

Description

ZAK is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]

Bioinformatics

Entrez	51776 Human
Uniprot	AAH01401 Human AAH01401.1 Human NM_133646 Human NP_057737 Human Q9NYL2 Human Q9NYL2-2 Human
Product By Gene ID	51776
Alternate Names	AZK EC 2.7.11 EC 2.7.11.25 HCCS-4 Human cervical cancer suppressor gene 4 protein Leucine zipper- and sterile alpha motif-containing kinase mitogen-activated protein kinase kinase kinase MLT mixed lineage kinase 7 mixed lineage kinase with a leucine zipper and a sterile alpha motif mixed lineage kinase-related kinase MRK-beta Mixed lineage kinase-related kinase MLK7 mlklak MLK-like mitogen-activated protein triple kinase MLK-related kinase MLT MLTK MRKcervical cancer suppressor gene 4 protein pk protein kinase sterile alpha motif and leucine zipper containing kinase AZK Sterile alpha motif- and leucine zipper-containing kinase AZK

Research Areas for ZAK

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Cell Cycle and Replication