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The Vesicle Associated Membrane Proteins (VAMP) or synaptobrevins are calcium binding proteins specific to eukaryotes. VAMPs, along with synaptosomal associated protein of 25 kDa (SNAP-25) and syntaxin, form the core complex of soluble NSF attachment protein receptor (SNARE) proteins that interact with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. These membrane associated proteins play a key role in the regulation of vesicle membrane fusion with the plasma membrane. The Clostridium tetani neurotoxin is a metalloprotease with specificity for VAMP. In Alzheimer®s disease, VAMP levels of all isoforms appear to be significantly lowered. It has been shown that the extreme carboxy-terminus of VAMP-1 is involved in subcellular vesicle targeting.
![Western Blot VAMP-1 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/VAMP-1_AF4828_Western_Blot_5561.jpg)
![Immunohistochemistry VAMP-1 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/VAMP-1_AF4828_Immunohistochemistry_6847.jpg)
