Leptin/OB Products

Description

Leptin, the obese (ob) gene product, is a small protein expressed in and secreted from adipose tissue of normal rodents. Studies suggest leptin acts as a circulating hormone capable of regulating body-weight homeostasis and energy balance. One possible target tissue for leptin is the hypothalamus, a proposed control center for satiety and energy expenditure. Ob gene knockout mice are characterized by several metabolic abnormalities including hyperglucocorticoidemia, hyperinsulinemia and insulin resistance, hyperglycemia, altered central nervous system activity, reduced metabolic rate of brown adipose tissue, and a large increase in white adipose tissue. Studies show that the administration of recombinant leptin to ob knockout mice reduces food intake and increases energy expenditure.

Bioinformatics

Entrez	16846 Mouse 25608 Rat 3952 Human
Uniprot	AAH60830 Human AAH60830.1 Human AAH69323 Human NM_000230 Human NP_000221 Human P41159 Human P41160 Mouse Q6NT58 Human
Product By Gene ID	3952
Alternate Names	FLJ94114 leptin (murine obesity homolog) leptin (obesity homolog, mouse) leptin Obese protein obese, mouse, homolog of Obesity factor OBOBS

Research Areas for Leptin/OB

Find related products by research area and learn more about each of the different research areas below.

Cytokine Research
Diabetes Research
Immunology
Lipid and Metabolism