E-Selectin/CD62E Products

Description

CD62E (also known as E-selectin, ELAM-1, and LECAM-1) is a 115 kD type I membrane protein and a member of the selectin family. CD62E is highly expressed on activated endothelial cells (IL-2, TNF- alpha, other cytokines can increase expression) and can also be expressed on endothelial cells in the skin, bone marrow and placenta. CD62E is involved in tethering and leucocyte rolling on activated endothelium at inflammatory sites and may also play a role in tumor metastasis and angiogenesis. CD62E binds to both Siayl Lewis X (CD15s) and PSGL-1 (CD162). The HCD62E antibody has been shown to recognize human CD62E and to be useful for flow cytometry.

Bioinformatics

Entrez	20339 Mouse 25544 Rat 6401 Human
Uniprot	NM_000450 Human NP_000441 Human P16581 Human
Product By Gene ID	6401
Alternate Names	CD62 antigen-like family member E CD62E antigen CD62E ELAM ELAM-1 ELAM1E-selectin endothelial adhesion molecule 1 Endothelial leukocyte adhesion molecule 1 ESEL LECAM2 leukocyte endothelial cell adhesion molecule 2 Leukocyte-endothelial cell adhesion molecule 2 selectin E

Research Areas for E-Selectin/CD62E

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Immunology
Lipid and Metabolism

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