5'-Nucleotidase/CD73 Products

Description

Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase; EC 3.1.3.5) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. The enzyme consists of a dimer of 2 identical 70-kD subunits bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane. The enzyme is used as a marker of lymphocyte differentiation. Consequently, a deficiency of NT5 occurs in a variety of immunodeficiency diseases (e.g., see MIM 102700, MIM 300300). Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate.[supplied by OMIM]

Bioinformatics

Entrez	4907 Human
Uniprot	AAH15940 Human AAH15940.1 Human NM_002526 Human NP_002517 Human P21589 Human
Product By Gene ID	4907
Alternate Names	5' nucleotidase (CD73) 5'-NT 5'-nucleotidase, ecto (CD73) CD73 antigen CD73 E5NT EC 3.1.3.5 Ecto-5'-nucleotidase ecto-5'-nucleotidase eN eNT NT NT55'-nucleotidase NTE Purine 5-Prime-Nucleotidase

Research Areas for 5'-Nucleotidase/CD73

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Lipid and Metabolism

Related 5'-Nucleotidase/CD73 Blog Posts

Check out the latest blog posts on 5'-Nucleotidase/CD73.

CD73 (Cluster of differentiation 73, ecto-5'-nucleotidase) CD73 is a 70kD glycosyl-phosphatidylinositol (GPI)-anchored cell surface molecule that belongs to the 5'-nucleosidase family. It hydrolyzes extracellular nucleotides into membrane permeable nucleosides and is found as both a membrane-bound and soluble...    Read more.

Adenosine Inhibits T cell Tumor Infiltration: KCa3.1, a New Anticancer Target By Yoskaly Lazo-Fernandez, PhD Role of Adenosine in the Tumor Microenvironment a Target for Cancer TherapyThe tumor microenvironment (TME) tends to be concentrated in the purine nucleoside adenosine, a direct resu...    Read more.

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