ADAM 23 Antibody
Chicken Polyclonal anti-ADAM 23
Price: $295.00
  • Catalog Number: NB100-75282
  • Unit Size: 0.05 mg
Product Images
Western Blot: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000, Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development. ( anti-ADAM23 ) 
Gene ID 8745 Reference Sequence O75077 
Species Summary Hu(+) Application Summary WB 
Purity Immunogen affinity purified Host Chicken 
Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Background

ADAM23 is a non-catalytic metalloprotease-like protein. It is highly expressed in the brain, primarily in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex and occipital pole, and weakly expressed in the heart. 3 isoforms are produced by alternative splicing, alpha, beta and gamma. ADAM23 may play a role in cell-cell and cell-matrix interactions. May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.
Isotype

IgY
Immunogen

The immunogen for this antibody was a sequence from 72a.a. to 144a.a. from ADAM 23(a 832a.a. long protein)
Localization

Nucleus.
Species Reactivity

This antibody is reactive against Human.
Uses

Western Blot: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000. Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development.
Dilutions

Western Blot
Theoretical Molecular Weight

91926 Da
Packaging

0.05 mg Immunogen affinity purified Chicken antisera
Buffer

Phosphate-Buffered Saline pH7.2
Preservative

0.02% sodium azide
Alternate Names

anti-A disintegrin and metalloproteinase domain 23 antibody, anti-MDC 3 antibody, anti-Metalloproteinase like disintegrin like and cysteine rich protein 3 antibody
Gene Symbol

ADAM23
 
 
 

[1] Takada,H., Imoto,I., Tsuda,H., Nakanishi,Y., Ichikura,T., Mochizuki,H., Mitsufuji,S., Hosoda,F., Hirohashi,S., Ohki,M. and, et al. ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation

[2] Costa,F.F., Colin,C., Shinjo,S.M., Zanata,S.M., Marie,S.K., Sogayar,M.C. and Camargo,A.A. ADAM23 methylation and expression analysis in brain tumors

[3] Brandenberger,R., Wei,H., Zhang,S., Lei,S., Murage,J., Fisk,G.J., Li,Y., Xu,C., Fang,R., Guegler,K., Rao,M.S., Mandalam,R.,, et al. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation

[4] Cal,S., Freije,J.M., Lopez,J.M., Takada,Y. and Lopez-Otin,C., et al. ADAM 23/MDC3, a human disintegrin that promotes cell adhesion via interaction with the alphavbeta3 integrin through an RGD-independent mechanism

[5] Roberts,C.M., Tani,P.H., Bridges,L.C., Laszik,Z. and Bowditch,R.D., et al. MDC-L, a novel metalloprotease disintegrin cysteine-rich protein family member expressed by human lymphocytes

[6] , Sagane K., Ohya Y., Hasegawa Y., Tanaka I. Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain.

[7] , Cal S., Freije J.M.P., Lopez J.M., Takada Y., Lopez-Otin C. ADAM 23/MDC3, a human disintegrin that promotes cell adhesion via interaction with the alpha v beta 3 integrin through an RGD-independent mechanism.

[8] , Sun Y.P., Deng K.J., Wang F., Zhang J., Huang X., Qiao S., Zhao S. Two novel isoforms of Adam23 expressed in the developmental process of mouse and human brains.