ABP Antibody
Rabbit Polyclonal anti-ABP
Price: $295.00
  • Catalog Number: NB100-56417
  • Unit Size: 0.1 mg
Product Images
Western blot analysis of ABP in (A) human brain and (B) human heart cell lysate using NB100-56417 at 1 ug/ml. 
Gene ID 6462 Reference Sequence  
Species Summary Hu(+) Mu(+) Rt(+) Po(+) Bv(+) Application Summary WB 
Purity protein G purified Host Rabbit 
Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles.
Background

The gene encodes an EF hand-containing small calcium binding protein. It is an integral subunit component of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Kv4 potassium channels regulate action potentials in neurons and cardiac myocytes. The coexpression of ABP with pore-forming Kv4 alpha subunits causes changes in the gating and amplitude of Kv4 currents, thus profoundly affect the intracellular trafficking and molecular properties of Kv4.2 alpha subunits. It also cause a dramatic redistribution of Kv4.2, releasing intrinsic endoplasmic reticulum retention and allowing for trafficking to the cell surface. It may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. It maps to 5q35.1 region of human chromosome. Alternative splicing results in multiple transcript variant encoding different isoforms. Isoform 1 and isoform 2 are expressed in brain and kidney.
Research Areas

Vision,    

Isotype

IgG
Immunogen

Amino acids 11-28 (LQTKQRRPSKDKIEDELE) of human ABP protein were used as the immunogen.
Specificity

The NCBI accession number for ABP is NP-055407. The amino acid sequence used as immunogen is 100% homologous in human, mouse, rat, pig and bovine.
Species Reactivity

Reacts with Human, mouse, rat, porcine and bovine.
Uses

Western Blot
Dilutions

Western Blot 0.5-2 ug/ml
Positive Controls

human brain or heart
Positive Controls:

* Human Brain Protein NB820-59177 * Human Heart Protein NB820-59217
Packaging

0.1 mg protein G purified Rabbit antisera.
Buffer

PBS containing 0.2% gelatin
Preservative

0.05% sodium azide
Alternate Names

anti-VABP antibody, anti-Vesicle APC-Binding Protein antibody, anti-KCHIP2 antibody
Gene Symbol

SHBG
 
 
 

1. Lin,Y.L., Chen,C.Y., Cheng,C.P. and Chang,L.S. Protein-protein interactions of KChIP proteins and Kv4.2. Biochem. Biophys. Res. Commun. 321 (3), 606-610 (2004).

2. Nakamura,T.Y., Nandi,S., Pountney,D.J., Artman,M., Rudy,B. and Coetzee,W.A. Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2. FEBS Lett. 499 (3), 205-209 (2001).

3. W. Frank An, Mark R. Bowlby, Maria Betty, Jie Cao, Huai-Ping Ling, Grace Mendoza, Joseph W. Hinson, Karen I. Mattsson, Brian W. Strassle, James S. Trimmer and Kenneth J. Rhodes. Modulation of A-type potassium channels by a family of calcium sensors; Nature 403, 553-556 (3 February 2000).