ACE2 Antibody
Rabbit Polyclonal anti-ACE2
Price: $335.00
  • Catalog Number: NB100-55874
  • Unit Size: 0.05 mg
Product Images
Western blot analysis of ACE2 in human kidney lysate with anti-ACE2 (NT) using NB100-55874 at 1 ug/ml. Immunohistochemical staining of human kidney cells using anti-ACE2 (NT) at 2 ug/ml. 
Gene ID 59272 Reference Sequence  
Species Summary Hu(+) Application Summary IHC, WB 
Purity  Host Rabbit 
Storage

Store at 4C. Do not freeze.
Background

Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
Isotype

IgG
Immunogen

Human ACE2 (NT) peptide.
Species Reactivity

Human Not yet tested in other species.
Uses

WB: 0.5-2 ug/ml ~; IHC (paraffin): 2 ug/ml
Dilutions

immunohistochemistry, Western Blot
Positive Controls

Human kidney or human testis cell lysate can be used as positive control.
Positive Controls:

* Human Kidney Protein NB820-59231 * Human Testis Protein NB820-59266
Packaging

0.05 mg Rabbit antisera.
Buffer

PBS containing 0.02% sodium azide.
Gene Symbol

ACE2