ACVRL1 Antibody
Goat Polyclonal anti-ACVRL1
Price: $195.00
  • Catalog Number: NB100-1396
  • Unit Size: 0.1 mg
Gene ID 94 Reference Sequence NP_000011. 
Species Summary Hu Application Summary ELISA, WB 
Purity Immunogen affinity purified Host Goat 
Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Background

**Please note, this product is one of a range of Investigative Grade antibodies, made against targets that have limited or no commercial antibodies available to them and for which there are no data on the expression of the protein in the range of common cell lines and tissues available to us. These antibodies are affinity purified using their peptide immunogen and are known to give low background staining in a western blot. However no additional claims are made for their ability to recognise native protein in any application. Activin A receptor, type II-like 1 is a type I cell-surface receptor for the TGF-beta superfamily of ligands. ACVRL1 is most highly expressed in human placenta and lung. ACVRL1 deficiency causes hemorrhagic telangiectasia type 2 (HHT2; MIM 600376 ) also known as Rendu-Osler-Weber syndrome 2 (ORW2).Note: ACVRL1 is also known as ALK1 - not to be confused with the similarly named ALK (anaplastic lymphoma kinase).
Isotype

IgG
Immunogen

Synthetic peptide: KISNSPEKPKVIQ representing the C-Terminus of the human protein (residues 491-503) according to NP_000011.

Species Reactivity

Human.
Uses

This antibody is useful for Peptide ELISA and Western Blot. Preliminary experiments gave no signal but low background in Human Lung and Liver extracts.
Dilutions

ELISA 1:32000, Western Blot 1µg/ml
Positive Controls

Lung and liver extracts.
Concentration

0.5 mg/ml
Positive Controls:

* Antigen standard for ACVRL1 (NM_000020) (transient overexpression lysate)
Packaging

0.1 mg Immunogen affinity purified Goat antisera.
Buffer

Tris saline containing [pH7.3] with 0.5% BSA
Preservative

0.02% Na azide
Alternate Names

anti-Activin A receptor antibody, anti-activin A receptor type II-like 1 antibody, anti-activin receptor-like kinase 1 antibody, anti-ACVRLK1 antibody, anti-ALK1 antibody, anti-HHT antibody, anti-HHT2 antibody, anti-ORW2 antibody, anti-SKR3 antibody, anti-type II-like kinase 1 antibody
Notes

**Please note, this product is one of a range of Investigative Grade antibodies, made against targets that have limited or no commercial antibodies available to them and for which there are no data on the expression of the protein in the range of common cell lines and tissues available to us. These antibodies are affinity purified using their peptide immunogen and are known to give low background staining in a western blot. However no additional claims are made for their ability to recognize native protein in any application.
Gene Symbol

ACVRL1
 
 
 

Johnson DW et al. Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2. Nat Genet 13:189-95 (1996).