The AKT signaling pathway plays an important regulatory role in many cellular survival pathways,
primarily as an inhibitor of apoptosis. AKT also plays a regulatory role in angiogenesis and metabolism. The AKT pathway is activated by factors that induce PI3K which in turn activates mTOR pathways. These pathways function in the inhibition of apoptosis as well as cell differentiation and cell cycle. AKT signaling has been implicated in various cancers and is an active area of interest for anti-cancer therapeutics.