Adiponectin/Acrp30 Products

Description

Adipose cells produce and secrete numerous physiologically important proteins, such as Lipoprotein Lipase, Leptin, and Adipocyte Complement Related protein of 30 kDa, also known as Acrp30 or Adiponectin. Adiponectin is a circulating protein that is secreted exclusively by differentiated adipocytes. During adipocyte differentiation, Adiponectin mRNA is induced >100 fold. Adiponectin improves the ability of insulin to suppress glucose production, at sub physiological levels, thereby linking adipose tissue to whole body glucose regulation. Adiponectin function appears to be regulated by phosphatidylinositol 3 kinase (PI3K) since Adiponectin secretion is blocked by pharmacologic inhibitors of this kinase. Adiponectin mRNA is significantly reduced in adipose tissue of obese patients with Type 2 diabetes. The structural similarity of Adiponectin to TNF alpha suggests that Adiponectin may play a role in pathogenesis of insulin resistance in Type 2 diabetes. Adiponectin is implicated as a regulator of whole body energy homeostasis.

Bioinformatics

Entrez	11450 Mouse 246253 Rat 9370 Human
Uniprot	NM_004797 Human NP_004788 Human NP_033735 Mouse Q15848 Human
Product By Gene ID	9370
Alternate Names	ACDC ACRP30ADPN adipocyte, C1Q and collagen domain containing adiponectin adiponectin, C1Q and collagen domain containing AdipoQ ADIPQTL1 apM-1 APM1APM-1 C1q and collagen domain-containing protein GBP28apM1 Gelatin-binding protein

Research Areas for Adiponectin/Acrp30

Find related products by research area and learn more about each of the different research areas below.

Diabetes Research
Lipid and Metabolism