Sirtuin 5/SIRT5 Products

Description

SIRT5 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in two transcript variants.

Bioinformatics

Entrez	23408 Human 306840 Rat 68346 Mouse
Uniprot	NP_036373 Human NP_036373.1 Human Q5T295 Human Q9NXA8 Human
Product By Gene ID	23408
Alternate Names	EC 3.5.1 EC 3.5.1.- FLJ36950 NAD-dependent deacetylase sirtuin-5 silent mating type information regulation 2, S.cerevisiae, homolog 5 SIR2L5 sir2-like 5 SIR2-like protein 5 sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 5 sirtuin 5 sirtuin type 5

Research Areas for Sirtuin 5/SIRT5

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Epigenetics
Histone Deacetylases