DNA methylation is an important epigenetic modification that is catalyzed by DNA methyltransferases (DNMTs), including DNMT1, DNMT3a and DNMT3b.  DNA methylation involves the addition of a methyl group from S-adenosyl-L-methionine to the fifth carbon position of cytosine, mostly within CpG dinucleotides.  DNMTs are classified as de novo methyltransferases or maintenance methyltransferases. Enzymes that methylate previously unmethylated CpG sequences are de novo methyltransferases. Enzymes that copy preexisting methylation marks onto new DNA strands during replication are maintenance methyltransferases.


Dnmt1
NB100-56519

Dnmt2
NB200-615

Dnmt3
NB120-13888

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