XPA Antibody

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Western Blot: XPA Antibody [NB100-92124] - (WB) analysis of XPA (H244) antibody in extracts from COLO205 cells.

Product Details

Summary
Product Discontinued
View other related XPA Primary Antibodies

Order Details


    • Catalog Number
      NB100-92124
    • Availability
      Product Discontinued

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XPA Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 215-260 of Human XPA.
Clonality
Polyclonal
Host
Rabbit
Gene
XPA
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of XPA (H244) pAb in extracts from COLO205 cells.
Theoretical MW
33 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Positive Control
XPA Lysate (NBL1-17907)

Reactivity Notes

This antibody is reactive against Human,Mouse,Rat.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for XPA Antibody

  • DNA repair protein complementing XP-A cells
  • excision repair-controlling
  • Xeroderma pigmentosum group A-complementing protein
  • xeroderma pigmentosum, complementation group A
  • XP1
  • XPA
  • XPACXP1

Background

Xeroderma pigmentosum (XP) is an autosomal recessive disorder characterized by a genetic predisposition to sunlight-induced skin cancer due to deficiencies in the DNA repair enzymes. The most frequent mutations are found in the XP genes of group A through G and group V, which encode nucleotide excision repair proteins. The XPA gene encodes a 31 kDa zinc metalloprotein that preferentially binds to DNA damaged by UV radiation and chemical carcinogens and is required for the incision step during nucleotide excision repair. The XPB and XPD genes encode DNA helicases involved in several DNA metabolic pathways, including DNA repair and transcription, and the XPG gene product is an endonuclease that cuts on the 3' side of a DNA lesion during nucleotide excision repair. Molecular defects in the XP variant (XPV) group maintain normal excision repair, yet they result in a substantial reduction in the ability to synthesize intact daughter DNA strands during DNA replication following DNA damage.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for XPA Antibody (NB100-92124)

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Research Areas for XPA Antibody (NB100-92124)

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Blogs on XPA.

Role of RASSF1A in Death Receptor-Dependent Apoptosis
Death-receptor apoptosis, or cell death, is essential for cellular growth regulation; its disruption is expressed in a variety of cancers. We at Novus Biologicals are one of the leading antibody suppliersfor apoptosis and cancer research groups, and t...  Read full blog post.

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Bioinformatics

Gene Symbol XPA
Entrez