| Reactivity | HuSpecies Glossary |
| Applications | WB |
| Clonality | Polyclonal |
| Host | Goat |
| Conjugate | Alexa Fluor 700 |
| Immunogen | E. coli-derived recombinant human XPA Met1-Met273 Accession # P23025 |
| Specificity | Detects human XPA in Western blots. |
| Isotype | IgG |
| Clonality | Polyclonal |
| Host | Goat |
| Purity Statement | Antigen Affinity-purified |
| Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
| Storage | Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied |
| Buffer | Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide |
The Xeroderma Pigmentosum A (XPA) protein is a component of a large complex that binds to damaged DNA to facilitate nucleotide excision repair (NER). XPA binds in a complex with Replication Protein A (RPA), XPG, and TFIIH (a subcomplex of the RNA polymerase II transcription initiation complex). XPA is thought to stabilize the binding of RPA to DNA, and thus aid in specific recognition of the damaged base. Because of their NER defect, XP patients exhibit hypersensitivity to ultraviolet light and have a heightened incidence of skin cancer.
![XPA Antibody [Alexa Fluor® 700]](/sites/all/modules/enterprise-tech/et_datasheets/images/novus_guarantee.png "XPA Antibody [Alexa Fluor® 700]")
Secondary Antibodies |
Isotype Controls |
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Role of RASSF1A in Death Receptor-Dependent Apoptosis Death-receptor apoptosis, or cell death, is essential for cellular growth regulation; its disruption is expressed in a variety of cancers. We at Novus Biologicals are one of the leading antibody suppliersfor apoptosis and cancer research groups, and t... Read full blog post. |
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