XIAP Antibody Summary
Antibody was raised against a synthetic peptide corresponding to 13 amino acids at the C-terminus of human XIAP. The immunogen is located within amino acids 420 - 470 of XIAP.
Immunogen affinity purified
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- Western Blot 1:100-1:2000
- ELISA 1:100-1:2000
- Immunohistochemistry 1:10-1:500
- Immunohistochemistry-Paraffin 1:10-1:500
- Immunofluorescence 10 ug/ml
XIAP antibody can be used for the detection of XIAP by Western blot at 0.5 to 2 mg/ml. Human kidney cell lysate can be used as positive control. Anti-XIAP is human and mouse reactive.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.02% Sodium Azide
Immunogen affinity purified
Alternate Names for XIAP Antibody
- API3X-linked inhibitor of apoptosis protein
- apoptosis inhibitor 3
- baculoviral IAP repeat-containing 4
- baculoviral IAP repeat-containing protein 4
- E3 ubiquitin-protein ligase XIAP
- EC 6.3.2.-
- IAP-like protein
- Inhibitor of apoptosis protein 3
- X-linked IAP
- X-linked inhibitor of apoptosis
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. The X-chromosome linked inhibitor of apoptosis (XIAP) contains 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspases–3, –7, and –9. Upregulation of XIAP expression can protect cells from apoptosis induced by low level radiation; conversely, decreased XIAP expression by antisense targeting resulted in increased cell death following low level radiation. Two negative regulators, termed XAF-1 and Smac, can bind and inhibit XIAP activity.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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