XIAP Antibody

Images

 
Western Blot: XIAP Antibody [NBP1-77173] - Human kidney lysate with XIAP antibody at 0.5 (lane A), 1 (lane B), and 2 (lane C) ug/ml, respectively.
Immunohistochemistry: XIAP Antibody [NBP1-77173] - Staining of XIAP in mouse kidney tissue with XIAP antibody at 5 ug/mL.
Immunohistochemistry: XIAP Antibody [NBP1-77173] - Staining of human kidney tissue using XIAP antibody at 2 ug/mL.
Immunofluorescence: XIAP Antibody [NBP1-77173] - Human Kidney tissue at 10 ug/mL.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-77173
    • Availability
      Product Discontinued

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XIAP Antibody Summary

Immunogen
Antibody was raised against a synthetic peptide corresponding to 13 amino acids at the C-terminus of human XIAP. The immunogen is located within amino acids 420 - 470 of XIAP.
Clonality
Polyclonal
Host
Rabbit
Gene
XIAP
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Immunofluorescence 10 ug/ml
Application Notes
XIAP antibody can be used for the detection of XIAP by Western blot at 0.5 to 2 mg/ml. Human kidney cell lysate can be used as positive control. Anti-XIAP is human and mouse reactive.

Reactivity Notes

Human, Mouse

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for XIAP Antibody

  • API3X-linked inhibitor of apoptosis protein
  • apoptosis inhibitor 3
  • baculoviral IAP repeat-containing 4
  • baculoviral IAP repeat-containing protein 4
  • BIRC4
  • BIRC4XLP2
  • E3 ubiquitin-protein ligase XIAP
  • EC 6.3.2.-
  • hIAP3
  • hIAP-3
  • hILP
  • IAP3
  • IAP-3
  • IAP-like protein
  • ILP
  • ILP1
  • Inhibitor of apoptosis protein 3
  • MIHA
  • XIAP
  • X-linked IAP
  • X-linked inhibitor of apoptosis

Background

Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. The X-chromosome linked inhibitor of apoptosis (XIAP) contains 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspases–3, –7, and –9. Upregulation of XIAP expression can protect cells from apoptosis induced by low level radiation; conversely, decreased XIAP expression by antisense targeting resulted in increased cell death following low level radiation. Two negative regulators, termed XAF-1 and Smac, can bind and inhibit XIAP activity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for XIAP Antibody (NBP1-77173)

Discover related pathways, diseases and genes to XIAP Antibody (NBP1-77173). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for XIAP Antibody (NBP1-77173)

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Research Areas for XIAP Antibody (NBP1-77173)

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Blogs on XIAP.

Apoptosis and Necroptosis Part II: Inhibitors of apoptosis proteins (IAPs); Key regulators of the balance between necroptosis, apoptosis and survival
In the first installment of this two-part blog post titled "Apoptosis and Necroptosis: Important factors to identify both types of programmed cell death", the mechanisms by which cell death occurs and ways to identify these pathways were...  Read full blog post.

Caspase 9 - an important apoptosis marker
Caspases are essential mediators of programmed cell death and are needed for both the induction of apoptosis as well as for aiding the degradation of cellular structures. Initiator caspases (such as Caspase-9) sense and respond to various signals i...  Read full blog post.

cIAP2 - balancing cell death and cell survival
The inhibitor of apoptosis proteins (IAPs) are important regulators of cell death and inflammation. The cellular inhibitor of apoptosis protein 2 (cIAP2) contains three Baculovirus IAP repeat (BIR) domains, a Ubiquitin associated (UBA) domain, and...  Read full blog post.

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Bioinformatics

Gene Symbol XIAP
Entrez
Uniprot