XCL1/Lymphotactin Antibody Summary
Peptide with sequence C-RDVVRSMDRKSNTRN corresponding to internal region according to NP_002986.1, NP_003166.1.
XCL1 and CXL2 are almost identical and therefore this antibody is expected to recognize both proteins.
Immunogen affinity purified
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- Peptide ELISA Detection limit 1:16000
WB: Preliminary experiments gave an approx. 80 kDa band in human peripheral blood mononucleocytes lysates after 0.3 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 12.5 kDa band according to NP_002986.1 and 12.6 kDa band according to 003166.1. The 80 kDa band was successfully blocked by incubation with the immunizing peptide.
Packaging, Storage & Formulations
Store at -20C. Avoid freeze-thaw cycles.
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
0.02% Sodium Azide
Immunogen affinity purified
Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at firstname.lastname@example.org for more details.
Alternate Names for XCL1/Lymphotactin Antibody
- ATACSmall-inducible cytokine C1
- C motif chemokine 1
- chemokine (C motif) ligand 1
- Cytokine SCM-1
- LTNXC chemokine ligand 1
- SCM-1 alpha
- single cysteine motif 1a
- small inducible cytokine subfamily C, member 1 (lymphotactin)
Mouse lymphotactin (Lptn)/XCL1 and its human homologue (also named human SCM1 and ATAC), members of the gamma or C subfamily of chemokines, are characterized by having only two cysteines. Mouse lymphotactin encodes a 114 amino acid precursor protein with a 21 amino acid predicted signal peptide. The gene for human and mouse lymphotactin has been mapped to chromosome 1. Human and mouse lymphotactin share approximately 60% amino acid sequence identity. The expression of lymphotactin is restricted to activated mouse pro-T cells and to activated, class I MHC restricted T cells. Since lymphotactin is produced by lymphocytes and acts on lymphocytes, it is speculated that it is a messenger in T cell chemoattraction. Mouse lymphotactin is chemotactic for lymphocytes, NK cells, and mouse splenocytes. It has been shown that lymphotactin is a key regulator of lymphocyte motility and adhesion during acute allograft rejection. The specific receptor for lymphotactin is the orphan receptor XCR1 (GPR5).
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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