XBP1 Antibody


Western Blot: XBP1 Antibody [H00007494-B01P] - Analysis of XBP1 expression in transfected 293T cell line by XBP1 polyclonal antibody. Lane 1: XBP1 transfected lysate(28.71 KDa). Lane 2: Non-transfected lysate.

Product Details

Reactivity HuSpecies Glossary
Applications WB, ELISA
Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Order Details

XBP1 Antibody Summary

XBP1 - X-box binding protein 1,
Protein A purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
PBS (pH 7.4)
No Preservative
Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.
Protein A purified


Application Notes
Antibody reactive against Recombinant Protein with GST tag on ELISA and Western Blot and also on transfected lysate in western blot. GST tag alone is used as a negative control.

Reactivity Notes



This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for XBP1 Antibody

  • HTF
  • TREB5
  • X-box binding protein 1
  • X-box-binding protein 1
  • XBP-1
  • XBP2
  • XBP2Tax-responsive element-binding protein 5


This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq]


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies


Isotype Controls

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Bioinformatics Tool for XBP1 Antibody (H00007494-B01P)

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Blogs on XBP1.

Analysis of Total & pSer724 IRE1 alpha, the Sensor of ER Stress
Inositol-requiring protein 1/IRE1 alpha (also called Endoplasmic Reticulum to Nucleus Signaling 1/ERN1; predicted mol wt 110 kDa) is a serine-threonine protein kinase/endoribonuclease which plays a highly critical role in unfolded protein response/U...  Read full blog post.

IRE1 - an important sensor in the unfolded protein response pathway
During cellular stress the protein folding capacity of the ER is diminished. In order to maintain homeostasis and ensure proper protein folding cells activate the unfolded protein response (UPR), a signaling network consisting of sensors and effect...  Read full blog post.

Contact Information

Product PDFs


Gene Symbol XBP1

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