WNK1 Antibody

Product Discontinued

WNK1 Antibody Summary

• Immunogen: Recombinant fragment corresponding to a region within amino acids 44 and 328 of WNK1 (Uniprot ID#Q9H4A3)
• Localization: Secreted
• Specificity: Human WNK1. The immunogen recognition regions are present in Isoforms 1, 2, 4 (HSN2), and 5.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: WNK1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:500-1:3000

Reactivity Notes

Tested in human. Not yet tested in any other species.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: 0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
• Preservative: 0.01% Thimerosal
• Purity: Immunogen affinity purified

Alternate Names for WNK1 Antibody

• EC 2.7.11
• EC 2.7.11.1
• Erythrocyte 65 kDa protein
• HSAN2hereditary sensory neuropathy, type II
• HSN2MGC163339
• hWNK1
• KDP
• KDPMGC163341
• KIAA0344
• Kinase deficient protein
• p65
• PHA2C
• PRKWNK1
• PRKWNK1PSK
• prostate-derived sterile 20-like kinase
• Protein kinase lysine-deficient 1
• Protein kinase with no lysine 1
• protein kinase, lysine deficient 1
• serine/threonine-protein kinase WNK1
• WNK lysine deficient protein kinase 1
• WNK1

Background

WNK lysine deficient protein kinase 1 (WNK1) is a cytoplasmic serine-threonine kinase expressed in the distal nephron which likely plays an important role in hypertension. WNK1 is responsible for controling Na+ and Cl- ion transport by inhibiting the activity of other related protein kinases, such as WNK4.

WNK1 mutations have been associated with Gordon hyperkalemia-hypertension syndrome (pseudohypoaldosteronism type II) and congenital sensory neuropathy.

WNK1 is also known as Human Accelerated Region 5, and is thought to have played a key role in differentiating humans from apes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for WNK1 Antibody (NBP1-32917)(1)

Publication using NBP1-32917

• Riviere JB, Ramalingam S, Lavastre V et al. KIF1A, an axonal transporter of synaptic vesicles, is mutated in hereditary sensory and autonomic neuropathy type 2. Am J Hum Genet 2011-08-12 [PMID: 21820098] (Human)

FAQs for WNK1 Antibody (NBP1-32917). (Showing 1 - 1 of 1 FAQ).

1. What is the sequence of the immunogen for NBP1-32917?
   • The immunogen for NBP1-32917 maps to a region found between amino acids 44-328 of WNK1. The sequence in itself is proprietary and cannot be disclosed.

Bioinformatics

• Gene Symbol: WNK1
• Entrez:
  • 65125(Human)
• Uniprot:
  • Q9H4A3()