VRL1 Antibody

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB110-75009
    • Availability
      Product Discontinued

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VRL1 Antibody Summary

Immunogen
A synthetic peptide as a part of human TRPV2 (VRL, VRL1, VRL-1, OTRPC2) conjugated to immunogenic carrier protein was used as the immunogen.
Specificity
TRPV2.
Clonality
Polyclonal
Host
Sheep
Gene
TRPV2
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:300-1:4000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Control
VRL1 Lysate (NBL1-17341)

Reactivity Notes

Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Whole antisera
Preservative
No Preservative
Concentration
LYOPH
Purity
Unpurified
Reconstitution Instructions
Reconstitute with 0.1 ml sterilized water to desired concentration.

Alternate Names for VRL1 Antibody

  • Osm-9-like TRP channel 2
  • transient receptor potential cation channel, subfamily V, member 2
  • TrpV2
  • Vanilloid receptor-like protein 1
  • VRL-1MGC12549
  • VRL1transient receptor potential cation channel subfamily V member 2
  • VRLOTRPC2

Background

This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. FUNCTION: Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. SUBUNIT: Homotetramer. Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with RGA. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cytoplasm. Melanosome. Note: Translocates from the cytoplasm to the plasma membrane upon ligand stimulation. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol TRPV2
Entrez
Uniprot