VEGF R3/Flt-4 ELISA Kit Summary
|Standard Curve Range
0.6 - 40.0 ng/mL
Packaging, Storage & Formulations
Storage of components varies. See protocol for specific instructions.
The human VEGF-R3/FLT-4 ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of human VEGF-R3/FLT-4
- Aluminium pouch(es) with a Microwell Plate coated with monoclonal antibody to human VEGF-R3/FLT-4
- Biotin-Conjugate anti-human VEGF-R3/FLT-4 monoclonal antibody
- Human VEGF-R3/FLT-4 Standard lyophilized, 80 ng/ml upon reconstitution
- Sample Diluent
- Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA)
- Wash Buffer Concentrate 20x (PBS with 1% Tween 20)
- Substrate Solution (tetramethyl-benzidine)
- Stop Solution (1M Phosphoric acid)
- Adhesive Films
Colored dyes for optional use with this kit are available and will be provided free of charge upon request. Please refer to catalog number NBP2-41404.
Alternate Names for VEGF R3/Flt-4 ELISA Kit
- EC 2.7.10
- EC 188.8.131.52
- fms-related tyrosine kinase 4
- soluble VEGFR3 variant 1
- soluble VEGFR3 variant 2
- soluble VEGFR3 variant 3
- Tyrosine-protein kinase receptor FLT4
- vascular endothelial growth factor receptor 3
- VEGFR3Fms-like tyrosine kinase 4
The main function of the lymphatic system is to return plasma back to the circulating blood. Plasma fluid, macromolecules and cells, such as leucocytes and activated antigen-presenting cells, enter the blind-ended lymphatic vessels. Lymph is then transported toward collecting lymphatic vessels and is returned to the blood circulation. Scientific studies over the past years have revealed a signal-transduction system for lymphatic endothelial cell growth, migration and survival. This system is formed by VEGF-C and VEGF-D and their shared receptor VEGFR-3/FLT-4. Homozygous deletion of VEGFR-3 in mice leads to defects in blood-vessel remodelling and embryonic death at mid-gestation, indicating an early vascular function for the receptor. Furthermore mouse studies suggest that upregulation and activation of VEGFR-3 have functional roles in sprouting angiogenesis and that VEGFR-3 is an important effector of the vascular phenotype resulting from Notch inhibition. In lymphoma patients, high expression of VEGFR-3 can been found in lymph endothelial cells isolated from the tumour tissue
This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed
for 6 months from date of receipt.
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