VDR/NR1I1/Vitamin D Receptor Antibody

Images

 
Western Blot: VDR/NR1I1/Vitamin D Receptor Antibody [NBP1-61794] - Analysis of extracts from MCF-7 cells, using Vitamin D Receptor Antibody. The lane on the right is treated with the synthesized peptide.
Immunocytochemistry/ Immunofluorescence: VDR/NR1I1/Vitamin D Receptor Antibody [NBP1-61794] - Analysis of HeLa cells, using Vitamin D Receptor Antibody. The picture on the right is treated with the synthesized peptide.
Immunohistochemistry-Paraffin: VDR/NR1I1/Vitamin D Receptor Antibody [NBP1-61794] - Analysis of paraffin-embedded human thyroid gland tissue, using Vitamin D Receptor Antibody. The picture on the right is treated with ...read more

Order Details


    • Catalog Number
      NBP1-61794
    • Availability
      Product Discontinued

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VDR/NR1I1/Vitamin D Receptor Antibody Summary

Immunogen
The antiserum was produced against synthesized peptide derived from human Vitamin D Receptor. The immunogen region is: Internal.
Specificity
Vitamin D Receptor (Ab-208) Antibody detects endogenous levels of total Vitamin D Receptor protein.
Clonality
Polyclonal
Host
Rabbit
Gene
VDR
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • ELISA 1:10000
  • Immunocytochemistry/Immunofluorescence 1:100-1:500
  • Immunohistochemistry 1:50-1:100
  • Immunohistochemistry-Paraffin 1:50-1:100
Application Notes
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
48 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS (without Mg2+ and Ca2+, pH 7.4), 0.15M NaCl and 50% Glycerol
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for VDR/NR1I1/Vitamin D Receptor Antibody

  • NR1I1
  • NR1I1Nuclear receptor subfamily 1 group I member 11,25-dihydroxyvitamin D3 receptor
  • VDR
  • vitamin D1,25- dihydroxyvitamin D3 receptor
  • vitamin D3 receptor

Background

The active metabolite of vitamin D modulates the expression of a wide variety of genes in a developmentally-specific manner. This secosteroid hormone can up- or downregulate the expression of genes involved in a diverse array of responses such as proliferation, differentiation and calcium homeostasis. 1,25-(OH)2-vitamin D3 exerts its effects through interaction with the vitamin D receptor (VDR), a member of the superfamily of hormone-activated nuclear receptors. In its ligand-bound state, the VDR forms heterodimers with the 9- cis retinoic acid receptor, RXR, and affects gene expression by binding specific DNA sequences known as hormone response elements, or HREs. In addition to regulating the above-mentioned cellular responses, 1,25-(OH)2-vitamin D3 exhibits antiproliferative properties in osteosarcoma, melanoma, colon carcinoma and breast carcinoma cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for VDR/NR1I1/Vitamin D Receptor Antibody (NBP1-61794) (0)

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol VDR
Entrez
Uniprot