VDR/NR1I1/Vitamin D Receptor Antibody (9A7g.E10.E4)

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Immunohistochemistry-Paraffin: VDR/NR1I1/Vitamin D Receptor Antibody (9A7g.E10.E4) [NBP1-39553] - Staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen ...read more

Order Details


    • Catalog Number
      NBP1-39553
    • Availability
      Product Discontinued

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VDR/NR1I1/Vitamin D Receptor Antibody (9A7g.E10.E4) Summary

Immunogen
A vitamin D receptor protein of amino acids 89 - 105 from chicken intestine (53kD).
Localization
Nuclear
Specificity
Recognizes both the occupied and unoccupied forms of VDR. Does not cross-react with estrogen and glucocorticoid receptors. In mammals, recognizes a protein of ~53kD which is identified as vitamin D Receptor (VDR). In avians, VDR appears as a doublet of 58 and 60kD. Species cross-reactivity: Human, porcine, mouse, rat, hamster, frog, chicken and fish.
Isotype
IgG2b
Clonality
Monoclonal
Host
Rat
Gene
VDR
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1-2 ug/ml
  • Gel Super Shift Assays 1:1-1:100
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 10 ug/ml

Reactivity Notes

Frog.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4) and 0.2% BSA
Preservative
0.09% Sodium Azide
Concentration
0.2 mg/ml
Purity
Protein G purified

Alternate Names for VDR/NR1I1/Vitamin D Receptor Antibody (9A7g.E10.E4)

  • NR1I1
  • NR1I1Nuclear receptor subfamily 1 group I member 11,25-dihydroxyvitamin D3 receptor
  • VDR
  • vitamin D1,25- dihydroxyvitamin D3 receptor
  • vitamin D3 receptor

Background

This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for VDR/NR1I1/Vitamin D Receptor Antibody (NBP1-39553) (0)

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Bioinformatics

Gene Symbol VDR
Entrez
Uniprot