VCAM-1/CD106 Antibody (1G11B1) [Biotin]

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-42359
    • Availability
      Product Discontinued

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VCAM-1/CD106 Antibody (1G11B1) [Biotin] Summary

Immunogen
The antibody reacts with VCAM-1, the vascular cell adhesion molecule (1), which is a member of the immunoglobulin superfamily.
Specificity
The antibody reacts with VCAM-1, the vascular cell adhesion molecule (1), which is a member of the immunoglobulin superfamily. The antigen is induced on human endotheli­al cells by TNF, IL-1, IFN-gamma or endotoxin. The ligand for VCAM-1 is VLA-4 (CD49d/CD29) an integrin that is constitutively expressed by thymocytes, lymphocytes and monocytes.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
VCAM1
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
Application Notes
The antibody is extremely useful for staining of VCAM-1 expressing endothelial cells. It permits staining of in vitro cultured cells and frozen tissue sections. It inhibits cellular adhesion. this antibody is useful in ELISA techniques.In vitro cultured cells can be fixed with 1% paraformaldehyde. Tissue sections are advised to be fixed for 10 min. in pure acetone and followed by incubation for 10 min in chloroform. Incubation with a pretested dilution of the antibody is advised to be i

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
No Buffer
Preservative
0.02% Sodium Azide
Purity
Protein A or G purified

Alternate Names for VCAM-1/CD106 Antibody (1G11B1) [Biotin]

  • CD106 antigen
  • CD106
  • DKFZp779G2333
  • INCAM-100
  • L1CAM
  • MGC99561
  • vascular cell adhesion molecule 1
  • vascular cell adhesion protein 1
  • V-CAM 1
  • VCAM1
  • VCAM-1

Background

VCAM1 is important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the integrins alpha4 beta1 (beta 1 integrin VLA4) and alpha4 beta7 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. VCAM1 is also expressed by several non endothelial cell types including some macrophages, follicular dendritic cells and bone marrow, stromal cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Additional VCAM-1/CD106 Products

Bioinformatics Tool for VCAM-1/CD106 Antibody (NBP1-42359)

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Diseases for VCAM-1/CD106 Antibody (NBP1-42359)

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PTMs for VCAM-1/CD106 Antibody (NBP1-42359)

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Bioinformatics

Gene Symbol VCAM1
Entrez