VCAM-1/CD106 Antibody (1G11B1) [Biotin] Summary
The antibody reacts with VCAM-1, the vascular cell adhesion molecule (1), which is a member of the immunoglobulin superfamily.
The antibody reacts with VCAM-1, the vascular cell adhesion molecule (1), which is a member of the immunoglobulin superfamily. The antigen is induced on human endothelial cells by TNF, IL-1, IFN-gamma or endotoxin. The ligand for VCAM-1 is VLA-4 (CD49d/CD29) an integrin that is constitutively expressed by thymocytes, lymphocytes and monocytes.
Protein A or G purified
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- ELISA 1:100-1:2000
- Immunohistochemistry 1:10-1:500
- Immunohistochemistry-Frozen 1:10-1:500
The antibody is extremely useful for staining of VCAM-1 expressing endothelial cells. It permits staining of in vitro cultured cells and frozen tissue sections. It inhibits cellular adhesion. this antibody is useful in ELISA techniques.In vitro cultured cells can be fixed with 1% paraformaldehyde. Tissue sections are advised to be fixed for 10 min. in pure acetone and followed by incubation for 10 min in chloroform. Incubation with a pretested dilution of the antibody is advised to be i
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
0.02% Sodium Azide
Protein A or G purified
Alternate Names for VCAM-1/CD106 Antibody (1G11B1) [Biotin]
- CD106 antigen
- vascular cell adhesion molecule 1
- vascular cell adhesion protein 1
- V-CAM 1
VCAM1 is important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the integrins alpha4 beta1 (beta 1 integrin VLA4) and alpha4 beta7 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. VCAM1 is also expressed by several non endothelial cell types including some macrophages, follicular dendritic cells and bone marrow, stromal cells.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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