VAV2 Antibody

Images

 
Western Blot: VAV2 Antibody [NBP1-19661] Extracts from THP1 cells.
Western Blot: VAV2 Antibody [NBP1-19661] - (WB) analysis of VAV2 (D138) antibody in extracts from NIH cells.

Product Details

Summary
Product Discontinued
View other related VAV2 Primary Antibodies

Order Details


    • Catalog Number
      NBP1-19661
    • Availability
      Product Discontinued

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VAV2 Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 100-150 of Human VAV2.
Clonality
Polyclonal
Host
Rabbit
Gene
VAV2
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunocytochemistry/Immunofluorescence 1:50-1:200
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of VAV2 (D138) pAb in extracts from THP1 cells.
Theoretical MW
108 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Cross reacts with Human and Mouse.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
15mM Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for VAV2 Antibody

  • guanine nucleotide exchange factor VAV2
  • oncogene VAV2
  • Protein vav-2
  • vav 2 guanine nucleotide exchange factor
  • vav 2 oncogene
  • VAV-2

Background

VAV2 is a ubiquitously expressed structural homolog of the VAV protooncogene that is expressed preferentially in hematopoetic cells. Both proteins are comprised of a Dbl homology (DH) domain with guanosine nucleotide exchange (GEF) activity exclusively directed towards Rho/Rac GTPases, a pleckstrin homology (PH) domain, a calponin-homology (CH) region, an acidic domain (AD) a zinc finger butterfly motif, two SH3 regions and one SH2 domain. GEF activity of RhoA family G proteins is induced by tyrosine phosphorylation in wild type VAV2, and is constitutively activated in N terminus deleted oncogene forms. Constitutive expression of a VAV2 oncoprotein may result in morphological alterations including highly enlarged cells in which karyokinesis and cytokinesis frequently are uncoupled.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Contact Information

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Bioinformatics

Gene Symbol VAV2
Entrez