Vav-1 [p Tyr174] Antibody

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Western Blot: Vav-1 Antibody [NBP1-51428] - Analyzes of p-Vav1 (Y174) pAb in extracts from Jurkat UV cells.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-51428
    • Availability
      Product Discontinued

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Vav-1 [p Tyr174] Antibody Summary

Immunogen
Synthetic phosphopeptide derived from human Vav1 around the phosphorylation site of Tyrosine 174.
Modification
p Tyr174
Specificity
p-Vav1 (Y174) pAb detects endogenous levels of Vav1 protein only when phosphorylated at Y174.
Clonality
Polyclonal
Host
Rabbit
Gene
VAV1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
Application Notes
Western blot (WB) analyzes of p-Vav1 (Y174) pAb in extracts from Jurkat UV cells.
Theoretical MW
100 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human, Mouse, Rat

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Vav-1 [p Tyr174] Antibody

  • oncogene vav
  • proto-oncogene vav
  • vav 1 guanine nucleotide exchange factor
  • vav proto-oncogene
  • Vav1
  • Vav-1
  • vav-T
  • VAVvav 1 oncogene

Background

The Vav gene was originally identified on the basis of its oncogenic activation during the course of gene transfer assays. The major translational product of the Vav proto-oncogene has been identified as a protein containing an array of structural motifs. Contained within its amino terminus are a helix-loop-helix domain and a leucine zipper motif similar to that of Myc family proteins; deletion of this region of p95Vav causes its oncogenic activation. In addition, p95Vav contains an SH2 domain, which could indicate its role as a substrate for tyrosine kinases. Expression of p95Vav is limited exclusively to cells of hematopoietic origin, including those of the erythroid, lymphoid and myeloid lineages. These results suggest that p95Vav may represent a new type of signal transduction molecule involved in the transduction of tyrosine phosphorylation signaling into transcriptional events.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol VAV1
Entrez