VASP [p Ser238] Antibody

Images

 
Western Blot: VASP [p Ser238] Antibody [NBP1-51427] - Analyzes of p-VASP (S238) pAb in extracts from NIH/3T3 cells.
Immunohistochemistry-Paraffin: VASP [p Ser238] Antibody [NBP1-51427] - Human cervix carcinoma tissue.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-51427
    • Availability
      Product Discontinued

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VASP [p Ser238] Antibody Summary

Immunogen
Synthetic phosphopeptide derived from human VASP around the phosphorylation site of Serine 238.
Modification
p Ser238
Marker
Focal Adhesion Marker
Specificity
p-VASP (S238) pAb detects endogenous levels of VASP protein only when phosphorylated at S238.
Clonality
Polyclonal
Host
Rabbit
Gene
VASP
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analyzes of p-VASP (S238) pAb in extracts from NIH/3T3 cells.
Immunohistochemistry (IHC) analyzes of p-VASP (S238) pAb in paraffin-embedded human cervix carcinoma tissue.
Theoretical MW
48 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human, Mouse, Rat

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for VASP [p Ser238] Antibody

  • vasodilator-stimulated phosphoprotein
  • VASP

Background

The Wiskott-Aldrich syndrome (WAS) is characterized by thrombocytopenia, eczema, defects in cell-mediated and humoral immunity and a propensity for lymphoproliferative diseases. The syndrome is the result of a mutation in the gene encoding a proline-rich protein termed WASP. A distantly related protein, VASP (vasodilator-stimulated phosphoprotein), is involved in the maintenance of cytoarchitecture by interacting with Actin-like filaments. VASP shares a limited degree of homology with the amino-terminus of WASP, which is frequently mutated in WAS patients. An established substrate of cAMP and cGMP dependent kinases, VASP is phosphorylated on a regulatory serine residue 157 and localizes to focal adhesions, microfilaments and highly active regions of the plasma membrane. VASP is also phosphorylated on Serine 239 by cGMP-dependent protein kinase.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol VASP
Entrez