VAMP-7 Antibody (SP11)

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-51748
    • Availability
      Product Discontinued

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VAMP-7 Antibody (SP11) Summary

Immunogen
Crude human synaptic immunoprecipitate.
Specificity
Appears to recognise the human synaptic vesicle protein synaptobrevin, VAMP, (3., 6.). Cross reacts with pig. Non-reactive with rat. Histology positive control tissue: Brain Immunogen: Crude human synaptic immunoprecipitate.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
VAMP7
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
The antibody is suitable for immunohistology on paraffin sections, ELISA and Western Blotting.This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections. Recommended dilution for Western blotting: 1:1000.

Reactivity Notes

Human, Porcine, Rat (-)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
0.2 mg purified material with PBS
Preservative
0.09% Sodium Azide
Purity
Protein A or G purified

Notes

This product should be stored undiluted.

Alternate Names for VAMP-7 Antibody (SP11)

  • FLJ54296
  • SYBL1
  • SYBL1FLJ53762
  • synaptobrevin-like 1
  • Synaptobrevin-like protein 1
  • tetanus neurotoxin-insensitive VAMP
  • Tetanus-insensitive VAMP
  • TIVAMP
  • TI-VAMP
  • VAMP7
  • VAMP-7
  • VAMP-7FLJ53045
  • vesicle-associated membrane protein 7

Background

SYBL1 (Synaptobrevin-like 1) involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation. Found ubiquitously and is an unusual v-SNAREs molecule implicated in cellular exocytosis. The SYBL1 gene is found on the pseudoautosomal region (PAR) of X chromosome. It is a highly conserved gene and has been shown to be silenced on inactive X and Y chromosomes. In ICF syndrome, a human disease affecting DNA methylation, SYBL1 escapes from silencing and this correlates with the observed altered patterns of histone methylation and acetylation found. An association between some SYBL1 alleles and bipolar affective disorder (BPAD) has been observed. SUBUNIT: Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that binds SYT7 during lysosomal exocytosis. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes in liver cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol VAMP7
Entrez