UNG Antibody

Images

 
Western Blot: UNG Antibody [NBP1-77259] - C2C12 cell lysate with uracil-DNA glycosylase antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
Immunohistochemistry-Paraffin: UNG Antibody [NBP1-77259] - Human heart tissue with uracil-DNA glycosylase antibody at 2 ug/ml.
Immunofluorescence: UNG Antibody [NBP1-77259] - Immunofluorescence of UNG1 in Human Heart cells with UNG1 antibody at 20 ug/mL.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, IHC, IHC-P, IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

UNG Antibody Summary

Immunogen
Antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human UNG1. The immunogen is located within the last 50 amino acids of UNG1.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
UNG
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.5-1 ug/ml
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 2 ug/ml
  • Immunofluorescence 20 ug/ml
Application Notes
UNG1 antibody can be used for the detection of UNG1 by Western blot at 0.5 - 1 mg/ml
Control Peptide
UNG Peptide (NBP1-77259PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for UNG Antibody

  • DGU
  • DGUEC 3.2.2
  • HIGM4EC 3.2.2.27
  • UDG
  • UDGDKFZp781L1143
  • UNG
  • UNG15
  • UNG1uracil-DNA glycosylase 1, uracil-DNA glycosylase 2
  • UNG2
  • uracil-DNA glycosylase

Background

The human uracil-DNA glycosylase (UNG) gene encodes both mitochondrial (UNG1) and nuclear (UNG2) forms through differentially regulated promotes and alternative splicing. While UNG2 is the major enzyme in the base excision repair pathway that removes uracil residues from nuclear DNA that arise through either misincorporation during replication or cytosine deamination, inhibition of UNG1 by uracil glycosylase inhibitor did not lead to increased levels of spontaneous or induced mitochondrial DNA mutations. However, decreased levels of UNG activity and increased oxidative damage to mitochondrial DNA were seen in older mice, suggesting that mitochondrial DNA repair mechanisms may be involved in various neurodegenerative disorders in an age-dependent manner. This UNG1 antibody will not cross-react with UNG2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

FAQs for UNG Antibody (NBP1-77259). (Showing 1 - 1 of 1 FAQ).

  1. Can you please send me all the info that you have about the antigen retrieval for this antibody?
    • The lab has confirmed that antigen retrieval was carried out. The recommended antigen retrieval is a heat mediated sodium citrate buffer at pH 5.5.

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol UNG
Entrez
Uniprot