TTF1 / NKX2.1 Antibody

Images

 
Western Blot: TTF1 / NKX2.1 Antibody [NBP1-19719] - Extracts from NIH/3T3 treated with EGF 200ng/ml 30'.
Immunohistochemistry-Paraffin: TTF1 / NKX2.1 Antibody [NBP1-19719] - Paraffin-embedded human breast carcinoma tissue at 1:100.
Immunohistochemistry-Paraffin: TTF1 / NKX2.1 Antibody [NBP1-19719] - Lung carcinoma tissue.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-19719
    • Availability
      Product Discontinued

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TTF1 / NKX2.1 Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 76-124 of Human TEBP.
Clonality
Polyclonal
Host
Rabbit
Gene
NKX2-1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:50-1:200
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of TEBP (K107) pAb in extracts from NIH/3T3 treated with EGF 200ng/ml 30'.
Immunohistochemistry (IHC) analyzes of TEBP (K107) pAb in paraffin-embedded lung carcinoma tissue.
Theoretical MW
18 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for TTF1 / NKX2.1 Antibody

  • BCH
  • benign chorea
  • BHC
  • Homeobox protein NK-2 homolog A
  • homeobox protein Nkx-2.1
  • NK2 homeobox 1
  • NK-2 homolog A
  • NKX2.1
  • NKX2-1
  • NKX2A
  • NKX2ANKX2.1
  • T/EBP
  • Thyroid nuclear factor 1
  • Thyroid transcription factor 1BHC
  • TITF1
  • TITF1TEBP
  • TTF1
  • TTF-1
  • TTF1BCH
  • TTF-1NK-2

Background

TTF-1 (Thyroid transcription factor-1, BCH, BHC, NK-2, Nkx2.1, Nkx2A, TEBP, TTF1) is a member of the Nkx2 family of homeodomain-containing transcription factors and regulates the transcriptional activity of thyroid-specific genes. TTF-1 is a 38 kDa protein that influences organogenisis and the maintenance of the differentiated phenotypes of various tissues including thyroid, lung and brain. TTF-1, which is present in the epithelium of the lung, regulates transcription of the surfactant proteins (SP) A, B, and C and is essential for lung morphogenesis. In the thyroid, TTF-1 elevates the expression of thyroid specific markers, thyroglobulin, thyroperoxidase and thyrotropin receptors. TTF-1 interacts with SRC-1 and CBP in vitro.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics Tool for TTF1 / NKX2.1 Antibody (NBP1-19719)

Discover related pathways, diseases and genes to TTF1 / NKX2.1 Antibody (NBP1-19719). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for TTF1 / NKX2.1 Antibody (NBP1-19719)

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PTMs for TTF1 / NKX2.1 Antibody (NBP1-19719)

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Research Areas for TTF1 / NKX2.1 Antibody (NBP1-19719)

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Blogs on TTF1 / NKX2.1.

TTF1 / NKX2.1 - An essential regulator of lung development with implications in cancer diagnostics
Thyroid transcription factor 1 (TTF-1), also known as NKX2.1, is a conserved master regulatory transcription factor involved in the development of the lung, brain, and thyroid (1). In the lung TTF-1 positively regulates the expression of several lu...  Read full blog post.

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Bioinformatics

Gene Symbol NKX2-1
Entrez