TTF1 / NKX2.1 Antibody (SPM150) [DyLight 405LS]

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Summary
Product Discontinued
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    • Catalog Number
      NBP2-34742V3
    • Availability
      Product Discontinued

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TTF1 / NKX2.1 Antibody (SPM150) [DyLight 405LS] Summary

Immunogen
Rat full length TTF-1 recombinant protein
Localization
Nuclear
Marker
Thyroid & Lung Epithelial Marker
Specificity
Recognizes a protein of 40kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates.Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
NKX2-1
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Conjugate
DyLight 405LS
Format
DyLight 405LS (A=397, E=572)
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Applications/Dilutions

Dilutions
  • Western Blot
  • ELISA
  • Flow Cytometry
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
Application Notes
Immunohistochemistry (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
Theoretical MW
40 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Shows broad species reactivity.

Alternate Names for TTF1 / NKX2.1 Antibody (SPM150) [DyLight 405LS]

  • benign chorea
  • Homeobox protein NK-2 homolog A
  • homeobox protein Nkx-2.1
  • NK2 homeobox 1
  • NK-2 homolog A
  • NKX2ANKX2.1
  • Thyroid nuclear factor 1
  • Thyroid transcription factor 1BHC
  • TITF1TEBP
  • TTF1
  • TTF1BCH
  • TTF-1NK-2

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TTF1 / NKX2.1 Antibody (NBP2-34742V3) (0)

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Product General Protocols

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for TTF1 / NKX2.1 Antibody (NBP2-34742V3) (0)

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Secondary Antibodies

 

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Bioinformatics Tool for TTF1 / NKX2.1 Antibody (NBP2-34742V3)

Discover related pathways, diseases and genes to TTF1 / NKX2.1 Antibody (NBP2-34742V3). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for TTF1 / NKX2.1 Antibody (NBP2-34742V3)

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Research Areas for TTF1 / NKX2.1 Antibody (NBP2-34742V3)

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Blogs on TTF1 / NKX2.1.

TTF1 / NKX2.1 - An essential regulator of lung development with implications in cancer diagnostics
Thyroid transcription factor 1 (TTF-1), also known as NKX2.1, is a conserved master regulatory transcription factor involved in the development of the lung, brain, and thyroid (1). In the lung TTF-1 positively regulates the expression of several lu...  Read full blog post.

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Bioinformatics

Gene Symbol NKX2-1