Reactivity | Hu, Mu, RtSpecies Glossary |
Applications | Flow |
Clone | 8G7G3/1 |
Clonality | Monoclonal |
Host | Mouse |
Conjugate | PE |
Immunogen | Rat full length TTF-1 recombinant protein |
Localization | Nuclear |
Marker | Thyroid & Lung Epithelial Marker |
Specificity | Recognizes a protein of 40kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates. Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies. |
Isotype | IgG1 Kappa |
Clonality | Monoclonal |
Host | Mouse |
Gene | NKX2-1 |
Purity | Protein A or G purified |
Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
Dilutions |
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Theoretical MW | 40 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Storage | Store at 4C in the dark. |
Buffer | PBS |
Preservative | 0.05% Sodium Azide |
Purity | Protein A or G purified |
Secondary Antibodies |
Isotype Controls |
Diseases for TTF1 / NKX2.1 Antibody (NBP2-34544PE)Discover more about diseases related to TTF1 / NKX2.1 Antibody (NBP2-34544PE).
| Pathways for TTF1 / NKX2.1 Antibody (NBP2-34544PE)View related products by pathway.
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TTF1 / NKX2.1 - An essential regulator of lung development with implications in cancer diagnostics Thyroid transcription factor 1 (TTF-1), also known as NKX2.1, is a conserved master regulatory transcription factor involved in the development of the lung, brain, and thyroid (1). In the lung TTF-1 positively regulates the expression of several lu... Read full blog post. |
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