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TTF1 / NKX2.1 Antibody (8G7G3/1) [PE]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications Flow
Clone
8G7G3/1
Clonality
Monoclonal
Host
Mouse
Conjugate
PE

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 405
NBP2-34544AF405
Alexa Fluor 488
NBP2-34544AF488
Alexa Fluor 647
NBP2-34544AF647
Alexa Fluor 700
NBP2-34544AF700
Allophycocyanin
NBP2-34544APC
Biotin
NBP2-34544B
DyLight 350
NBP2-34544UV
DyLight 405
NBP2-34544V
DyLight 488
NBP2-34544G
DyLight 550
NBP2-34544R
DyLight 650
NBP2-34544C
DyLight 680
NBP2-34544FR
DyLight 755
NBP2-34544IR
HRP
NBP2-34544H
PerCP
NBP2-34544PCP
Unconjugated
NBP2-44498-0.1mg
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-44498-0.1mg
Azide and BSA Free
NBP2-34544-0.1 mg
Azide and BSA Free
NBP2-34544-0.2 mg
IHC-Prediluted
NBP2-48103
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TTF1 / NKX2.1 Antibody (8G7G3/1) [PE] Summary

Immunogen
Rat full length TTF-1 recombinant protein
Localization
Nuclear
Marker
Thyroid & Lung Epithelial Marker
Specificity
Recognizes a protein of 40kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates. Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
NKX2-1
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • Flow Cytometry
Theoretical MW
40 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human, Mouse, and Rat. Shows a broad species reactivity.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for TTF1 / NKX2.1 Antibody (8G7G3/1) [PE]

  • BCH
  • benign chorea
  • BHC
  • Homeobox protein NK-2 homolog A
  • homeobox protein Nkx-2.1
  • NK2 homeobox 1
  • NK-2 homolog A
  • NKX2.1
  • NKX2-1
  • NKX2A
  • NKX2ANKX2.1
  • T/EBP
  • Thyroid nuclear factor 1
  • Thyroid transcription factor 1BHC
  • TITF1
  • TITF1TEBP
  • TTF1
  • TTF-1
  • TTF1BCH
  • TTF-1NK-2

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Immunohistochemistry-Paraffin: Cytokeratin 7 Antibody [NBP1-88080] - Staining in human placenta and skeletal muscle tissues. Corresponding KRT7 RNA-seq data are presented for the same tissues.
Western Blot: Cytokeratin 7 Antibody [NBP1-88080] - Analysis in human cell line SiHa.
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SP-B/Surfactant
Protein B Antibody
NBP1-57977
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Thyroid Peroxidase
Antibody
NBP1-80670
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Immunohistochemistry-Paraffin: Thyroid Peroxidase Antibody [NBP1-80670] - Staining in human thyroid gland and cerebral cortex tissues using anti-TPO antibody. Corresponding TPO RNA-seq data are presented for the same tissues.
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NBP1-32440
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Prosurfactant
Protein C Antibody
NBP1-87201
Western Blot: Prosurfactant Protein C Antibody [NBP1-87201] - Analysis in human lung tissue.
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Immunohistochemistry-Paraffin: Prosurfactant Protein C Antibody [NBP1-87201] - Staining of human lung shows high expression.
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CKAP4/p63 Antibody
NBP1-26642
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p63/TP73L Antibody
[Unconjugated]
AF1916
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AF231
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Antibody
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(OTI1H3)
NBP2-45677
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Publications for TTF1 / NKX2.1 Antibody (NBP2-34544PE) (0)

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Blogs on TTF1 / NKX2.1.

Check out the latest blog posts on TTF1 / NKX2.1.
TTF1 / NKX2.1 - An essential regulator of lung development with implications in cancer diagnostics
Thyroid transcription factor 1 (TTF-1), also known as NKX2.1, is a conserved master regulatory transcription factor involved in the development of the lung, brain, and thyroid (1). In the lung TTF-1 positively regulates the expression of several lu...  Read full blog post.

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Bioinformatics

Gene Symbol NKX2-1
Entrez