Recombinant Human TSLP Protein Summary
A recombinant protein corresponding to Human TSLP
|Details of Functionality
Biological Activity: The ED50 determined by the ability to induce proliferation of human Interleukin-7 receptor a & human TSLP Receptor co-transfected with mouse BaF3 cells was found to be less than 0.3 ng/ml.
Results: <0.3 ng/ml
| Protein/Peptide Type
Packaging, Storage & Formulations
Store at -20C. Avoid freeze-thaw cycles.
Reconstitute with sterilized deionized water to a final concentration of 0.1 - 1.0 mg/ml.
The purity of this protein is >95% pure by SDS-PAGE
Alternate Names for Recombinant Human TSLP Protein
- thymic stromal lymphopoietin
TSLP protein is a hemopoietic cytokine which signals throughout a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor & the Interleukin-7 receptoralpha chain. TSLP impacts myeloid cells thus induces the discharge of T cell-attracting chemokines from monocytes & increases the growth of CD11c(+) dendritic cells. TSLP is mainly expressed in the heart, liver and prostate. TSLP is related in its biological activities with IL-7 and binds with the heterodimeric receptor complex consisting of the Interleukin-7 receptoralpha chain & the TSLPR. Similar to IL-7, TSLP enhances phosphorylation of STAT3 and STAT5, though uses kinases excluding JAKs for its activation. TSLP induces the release of T cell-attracting chemokines such asTARC & MDC from monocytes & triggers CD11c(+) dendritic cells. TSLP activated dendritic cells primes naive T cells to manufacture pro-allergic cytokines such as Iinterleukin-4, Interleukin-5, Interleukin-13 and TNF-alpha whereas down-regulating Interleukin-10 and IFN-gamma play a role in the initiation of allergic inflammation. Recombinant human TSLP produced in E. coli is a single, non-glycosylated polypeptide chain containing 132 amino acids and having a molecular mass of 15 kDa
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed
for 3 months from date of receipt.
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