Recombinant Human TSLP Protein

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Summary
Product Discontinued
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    • Catalog Number
      NBP1-99561
    • Availability
      Product Discontinued

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Recombinant Human TSLP Protein Summary

Description
A recombinant protein corresponding to Human TSLP
Preparation
Method
>97% SDS-PAGE
Details of Functionality
Biological Activity: The ED50 determined by the ability to induce proliferation of human Interleukin-7 receptor a & human TSLP Receptor co-transfected with mouse BaF3 cells was found to be less than 0.3 ng/ml.
Results: <0.3 ng/ml
Protein/Peptide Type
Recombinant Protein
Gene
TSLP
Purity
>90% SDS-PAGE
Endotoxin Note
<0.1 ng/ug

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Concentration
Lyoph
Purity
>90% SDS-PAGE
Reconstitution Instructions
Reconstitute with sterilized deionized water to a final concentration of 0.1 - 1.0 mg/ml.

Notes

The purity of this protein is >95% pure by SDS-PAGE

Alternate Names for Recombinant Human TSLP Protein

  • thymic stromal lymphopoietin
  • TSLP

Background

TSLP protein is a hemopoietic cytokine which signals throughout a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor & the Interleukin-7 receptoralpha chain. TSLP impacts myeloid cells thus induces the discharge of T cell-attracting chemokines from monocytes & increases the growth of CD11c(+) dendritic cells. TSLP is mainly expressed in the heart, liver and prostate. TSLP is related in its biological activities with IL-7 and binds with the heterodimeric receptor complex consisting of the Interleukin-7 receptoralpha chain & the TSLPR. Similar to IL-7, TSLP enhances phosphorylation of STAT3 and STAT5, though uses kinases excluding JAKs for its activation. TSLP induces the release of T cell-attracting chemokines such asTARC & MDC from monocytes & triggers CD11c(+) dendritic cells. TSLP activated dendritic cells primes naive T cells to manufacture pro-allergic cytokines such as Iinterleukin-4, Interleukin-5, Interleukin-13 and TNF-alpha whereas down-regulating Interleukin-10 and IFN-gamma play a role in the initiation of allergic inflammation. Recombinant human TSLP produced in E. coli is a single, non-glycosylated polypeptide chain containing 132 amino acids and having a molecular mass of 15 kDa

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol TSLP
Entrez