Recombinant TSLP Protein Summary
A partial protein corresponding to TSLP.
Insect cell expressed N-terminal His-Tagged amino acids Tyr20-Glu140 of mTSLP (accession #NM_021367).
|Details of Functionality
This recombinant mouse TSLP has been tested in a Nag8/7 cell proliferation assay with an observed ED50 of 0.15 ng/ml, corresponding to a specific activity of approximately 6x10^6 Units/mg.
| Protein/Peptide Type
Partial Recombinant Protein
Less than 0.1 ng/ug cytokine as determined by the LAL assay.
This protein was made to the human sequence.
Packaging, Storage & Formulations
Store at -80C. Avoid freeze-thaw cycles.
Sterile liquid; 20 mM NaH2PO4, 0.15M NaCl, pH 7.2 with 1.0% BSA. 0.22 um filtered.
0.09% Sodium Azide
Purity: Greater than 99%, as determined by SDS-PAGE
Alternate Names for Recombinant TSLP Protein
- thymic stromal lymphopoietin
Thymic Stromal Lymphopoietin (TSLP) is a member of the B cell-stimulating factor family. Originally identified from the conditioned medium of a mouse thymic stromal cell line that promoted B-cell development, TSLP is expressed in thymus, spleen, kidney, lung, and bone marrow. TSLP activity overlaps with that of IL-7, playing a key role in the development of B cells, as well as stimulating the growth of thymocytes and T cells. TSLP stimulates monocytes to produce T cell-attracting chemokines such as TARC (CCL17) and MDC (CCL22). TSLP also activates dendritic cell-primed CD4 T cells to produce Th2 cytokines, including IL-4, IL-5, IL-13, and TNFalpha. This hematopoietic cytokine binds to a heterodimeric receptor complex consisting of the IL-7R alpha chain (IL-7Ralpha) and the TSLP-specific chain (TSLPR). Binding induces activation of STAT3 and STAT5 via phosphorylation. Mouse TSLP shares approximately 43% amino acid sequence identity with human TSLP. Recombinant mouse TSLP is a 15.0 kDa protein consisting of 121 amino acid residues.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed
for 3 months from date of receipt.
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