TSC2 [p Ser664] Antibody (Poly6359)

Images

 
Immunocytochemistry/ Immunofluorescence: TSC2 [p Ser664] Antibody (Poly6359) [NB100-78564] - Untreated Hela cells (Panel A), or overnight nocodazole treated Hela cells (Panel B) stained with purified rabbit polyclonal ...read more
Immunohistochemistry-Paraffin: TSC2 [p Ser664] Antibody (Poly6359) [NB100-78564] - Formalin-fixed paraffin-embedded human epidermis tissue was stained with Poly6359 and developed with an alkaline phosphatase chromogen ...read more
Immunocytochemistry/ Immunofluorescence: TSC2 [p Ser664] Antibody (Poly6359) [NB100-78564] - Untreated Hela cells (Panel A), or overnight nocodazole treated Hela cells (Panel B) stained with purified rabbit polyclonal ...read more

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-78564
    • Availability
      Product Discontinued

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TSC2 [p Ser664] Antibody (Poly6359) Summary

Immunogen
Modified peptide
Modification
p Ser664
Localization
Cytoplasm
Specificity
TSC2 Phosphospecific [Ser664]
Clonality
Monoclonal
Host
Rabbit
Gene
TSC2
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence 1:100~1:400
  • Immunohistochemistry 1:50
  • Immunohistochemistry-Paraffin 1:50
Application Notes
Antigen retrieval for IHC of formalin-fixed paraffin-embedded tissue using 0.01 M sodium citrate buffer is recommended.
Publications
Read Publications using NB100-78564.

Reactivity Notes

Human.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS (pH 7.2) and 50% Glycerol
Preservative
0.09% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein A or G purified

Alternate Names for TSC2 [p Ser664] Antibody (Poly6359)

  • LAM
  • LAMFLJ43106
  • TSC2
  • TSC4
  • Tuberin
  • Tuberous sclerosis 2 protein
  • tuberous sclerosis 2

Background

Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder that is caused by mutation in either the TSC1 (hamartin) or TSC2 (tuberin) gene. TSC1 and TSC2 proteins form a physical and functional heterodimer in vivo that inhibits ribosomal protein S6 kinase 1 (S6K1) and activates eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) by inhibition of the mammalian target of rapamycin (mTOR). TSC2 belongs to small GTPase protein of the Ras superfamily, contain a Rap-GAP domain. Predicted molecular weight 201 kD. Ser664 TSC2 phosphorylation leads to TSC1-TSC2 dissociation and markedly impairs TSC2 ability to inhibit mTOR signaling, cell proliferation, and oncogenic transformation. Erk (extracellular signal-regulated kinase) may contribute to tumorigenesis by phosphorylating TSC2 at specific residues, particularly S664. The Poly6359 antibody recognizes human phospho-TSC2 (Ser664) and has been shown to be useful for immunoflorence staining. This antibody does not detect TSC2 phosphorylated at other sites.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TSC2 Antibody (NB100-78564)(2)

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics Tool for TSC2 Antibody (NB100-78564)

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Research Areas for TSC2 Antibody (NB100-78564)

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Blogs on TSC2.

TSC2 - GTPase activating protein involved in cell cycle inhibition
TSC2 is a tumor suppressor gene that encodes a 200 kDa protein called tuberin. TSC2 heterodimerizes with TSC1 to form a complex with GTPase-activating protein (GAP) activity. The C-terminus of TSC2 contains the GAP domain responsible for this cata...  Read full blog post.

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Bioinformatics

Gene Symbol TSC2
Entrez
Uniprot