Tryptophan hydroxylase 2 [p Ser19] Antibody

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Product Details

Summary
Reactivity Mu, Rt, Bv, ZeSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

Tryptophan hydroxylase 2 [p Ser19] Antibody Summary

Immunogen
Synthetic phospeptide corresponding to an amino acid sequence within TPH2, which includes phosphorylated Ser19.
Modification
p Ser19
Specificity
NB100-66367 specifically recognizes the 55kDa Tryptophan Hydroxylase 2 (TPH2) protein, when phosphorylated at Ser19. Tryptophan Hydroxylase (TPH) is a rate-limiting enzyme which catalyses the 5-hydroxylation of tryptophan, to form the amino acid 5-hydroxytryptophan (5-HTP), in the first stage of the biosynthesis of the neurotransmitter serotonin (5-hydroxytryptamine/5HT). Mammalian TPH is encoded by two genes: TPH1 expressed in peripheral tissues e.g. skin and gut, and TPH2 primarily expressed in the brain. Studies have demonstrated the regulation/enhancement of TPH activity through phosphorylation by cAMP−dependent protein kinase (PKA) and Ca2+/calmodulin kinase II (CaMKII), the latter of which phosphorylates a Ser19 site within the regulatory domain of TPH2.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TPH2
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:1000
Application Notes
Western Blot detects a band of approximately 55kDa on recombinant TPH2 incubated in the presence of CAMKII.

Reactivity Notes

Rat. Based on sequence similarity, is expected to react with Bovine, Zebrafish and Mouse.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
10mM HEPES (pH 7.5)
Preservative
0.09% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for Tryptophan hydroxylase 2 [p Ser19] Antibody

  • ADHD7
  • EC 1.14.16
  • EC 1.14.16.4
  • FLJ37295
  • MGC138872
  • Neuronal tryptophan hydroxylase
  • NTPH
  • NTPHMGC138871
  • TPH2
  • tryptophan 5-hydroxylase 2
  • Tryptophan 5-monooxygenase 2
  • Tryptophan Hydroxylase 2

Background

TPH2 is a protein of the pterin dependent aromatic acid hydroxylase family. It catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. TPH2 is expressed predominantly in the central nervous system. Mutations in TPH2 gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol TPH2
Entrez
Uniprot