TRPM7 Antibody

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Product Details

Summary
Product Discontinued
View other related TRPM7 Primary Antibodies

Order Details


    • Catalog Number
      NBP1-20264
    • Availability
      Product Discontinued

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TRPM7 Antibody Summary

Immunogen
A synthetic peptide from the 4th cytoplasmic loop of human TRPM7 (LTRPC7) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity
TRPM7.
Clonality
Polyclonal
Host
Sheep
Gene
TRPM7
Purity
IgG purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 10-50 ug/ml
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500

Reactivity Notes

Human, rat.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
No Preservative
Concentration
LYOPH
Purity
IgG purified
Reconstitution Instructions
Reconstitute with 0.5 ml sterilized water. Add glycerol (1:1) for additional stability.

Alternate Names for TRPM7 Antibody

  • CHAK
  • CHAK1FLJ25718
  • Channel-kinase 1
  • EC 2.7.11.1
  • Long transient receptor potential channel 7
  • LTRPC ion channel family member 7
  • LTrpC7
  • LTrpC-7
  • LTRPC7FLJ20117
  • transient receptor potential cation channel subfamily M member 7
  • transient receptor potential cation channel, subfamily M, member 7
  • transient receptor potential-phospholipase C-interacting kinase
  • TRP-PLIK

Background

TRPCs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.; FUNCTION: Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).; CATALYTIC ACTIVITY: ATP + a protein: ADP + a phosphoprotein.; COFACTOR: Binds 1 zinc ion per subunit.; SUBUNIT: Homodimer. Forms heterodimers with TRPM6.; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics Tool for TRPM7 Antibody (NBP1-20264)

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Blogs on TRPM7.

Winter is coming, and TRPM8 welcomes the cold!
TRPM8, or transient receptor potential melastatin 8, is a nonselective cation channel that is activated by cold environments and menthol-like cooling compounds.  While TRPM8 is best known for its location in peripheral nerve endings, it has functio...  Read full blog post.

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Bioinformatics

Gene Symbol TRPM7
Entrez
Uniprot