TRPM4 Antibody (14F1)

Images

 
Western Blot: TRPM4 Antibody (14F1) [NBP1-48037] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TRPM4 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates ...read more
Immunohistochemistry-Paraffin: TRPM4 Antibody (14F1) [NBP1-48037] Staining of paraffin-embedded pancreas tissue using anti-TRPM4 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: TRPM4 Antibody (14F1) [NBP1-48037] - Staining of paraffin-embedded liver tissue using anti-TRPM4 mouse monoclonal antibody.

Product Details

Summary
Product Discontinued
View other related TRPM4 Primary Antibodies

Order Details


    • Catalog Number
      NBP1-48037
    • Availability
      Product Discontinued

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TRPM4 Antibody (14F1) Summary

Immunogen
Protein expressed in 293T cell transfected with human TRPM4 expression vector
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
TRPM4
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.3), 1.0% BSA and 50% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for TRPM4 Antibody (14F1)

  • Calcium-activated non-selective cation channel 1
  • FLJ20041
  • hTRPM4
  • Long transient receptor potential channel 4
  • LTRPC4
  • LTrpC-4
  • melastatin-4
  • PFHB1B
  • transient receptor potential cation channel subfamily M member 4
  • transient receptor potential cation channel, subfamily M, member 4
  • TRPM4B

Background

Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Blogs on TRPM4.

Winter is coming, and TRPM8 welcomes the cold!
TRPM8, or transient receptor potential melastatin 8, is a nonselective cation channel that is activated by cold environments and menthol-like cooling compounds.  While TRPM8 is best known for its location in peripheral nerve endings, it has functio...  Read full blog post.

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Bioinformatics

Gene Symbol TRPM4
Entrez
Uniprot