TRPM4 Antibody (10H5)

Images

 
Western Blot: TRPM4 Antibody (10H5) [NBP1-48036] Analysis of extracts (35ug) from 9 different cell lines by using anti-TRPM4 monoclonal antibody.
Immunohistochemistry-Paraffin: TRPM4 Antibody (10H5) [NBP1-48036] - Staining of paraffin-embedded Human pancreas tissue using anti-TRPM4 mouse monoclonal antibody.
Western Blot: TRPM4 Antibody (10H5) [NBP1-48036] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TRPM4 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates ...read more
Immunohistochemistry-Paraffin: TRPM4 Antibody (10H5) [NBP1-48036] - Staining of paraffin-embedded Carcinoma of Human liver tissue using anti-TRPM4 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: TRPM4 Antibody (10H5) [NBP1-48036] - Staining of paraffin-embedded Human Kidney tissue using anti-TRPM4 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: TRPM4 Antibody (10H5) [NBP1-48036] - Staining of paraffin-embedded Human liver tissue using anti-TRPM4 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: TRPM4 Antibody (10H5) [NBP1-48036] - Staining of paraffin-embedded Human Ovary tissue using anti-TRPM4 mouse monoclonal antibody.

Product Details

Summary
Reactivity Hu, Ca, PmSpecies Glossary
Applications WB, IHC, IHC-P
Clone
10H5
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

TRPM4 Antibody (10H5) Summary

Immunogen
Full length human recombinant protein of human TRPM4 (NP_060106) produced in HEK293T cell.
Specificity
This antibody is specific for Homo sapiens transient receptor potential cation channel, subfamily M, member 4 (TRPM4).
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
TRPM4
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:5000-10000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50

Reactivity Notes

Human, Canine, Monkey.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.3), 1.0% BSA and 50% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for TRPM4 Antibody (10H5)

  • Calcium-activated non-selective cation channel 1
  • FLJ20041
  • hTRPM4
  • Long transient receptor potential channel 4
  • LTRPC4
  • LTrpC-4
  • melastatin-4
  • PFHB1B
  • transient receptor potential cation channel subfamily M member 4
  • transient receptor potential cation channel, subfamily M, member 4
  • TRPM4B

Background

Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

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TRPM8, or transient receptor potential melastatin 8, is a nonselective cation channel that is activated by cold environments and menthol-like cooling compounds.  While TRPM8 is best known for its location in peripheral nerve endings, it has functio...  Read full blog post.

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Bioinformatics

Gene Symbol TRPM4
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