TRPA1 Antibody

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-03455
    • Availability
      Product Discontinued

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TRPA1 Antibody Summary

Immunogen
A synthetic from the 4th cytoplasmic loop of human transient receptor potential cation channel subfamily A member 1 (TRPA1, ANKTM1) conjugated to an immunogenic carrier protein was used as the immunogen.
Localization
subcellular location: membrane; multi-pass membrane protein (probable). tissue specificity: expressed at very low level. expressed at very low level in human fibroblasts and at a moderate level in liposarcoma cells.
Specificity
TRPA1.
Clonality
Polyclonal
Host
Sheep
Gene
TRPA1
Purity
Unpurified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:300-1:3000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500

Reactivity Notes

Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Whole antisera
Preservative
No Preservative
Concentration
LYOPH
Purity
Unpurified
Reconstitution Instructions
Reconstitute with 0.1 ml sterilized water to desired concentration.

Alternate Names for TRPA1 Antibody

  • ANKTM1ankyrin-like with transmembrane domains 1
  • Ankyrin-like with transmembrane domains protein 1
  • Transformation-sensitive protein p120
  • transient receptor potential cation channel subfamily A member 1
  • transient receptor potential cation channel, subfamily A, member 1

Background

The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. the specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. function: receptor-activated non-selective cation channel involved in detection of sensations such as cold, pain or sounds perception. has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicle exhaust fumes. also involved in pain sensation triggered by capsaicin, the pungent ingredient in chili peppers. acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (thc), the psychoactive component of marijuana. not involved in menthol sensation. may be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. probably operated by a phosphatidylinositol second messenger system.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

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Bioinformatics Tool for TRPA1 Antibody (NBP1-03455)

Discover related pathways, diseases and genes to TRPA1 Antibody (NBP1-03455). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for TRPA1 Antibody (NBP1-03455)

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Blogs on TRPA1.

Winter is coming, and TRPM8 welcomes the cold!
TRPM8, or transient receptor potential melastatin 8, is a nonselective cation channel that is activated by cold environments and menthol-like cooling compounds.  While TRPM8 is best known for its location in peripheral nerve endings, it has functio...  Read full blog post.

TRPA1: A contributor to itching and inflammation? Scratch that!
Transient receptor potential A1 (TRPA1) is an ion channel found on the plasma membrane of many cell types that functions in diverse sensory processes such as pain and temperature. The TRPA1 ion channel is specifically expressed in nociceptive neurons,...  Read full blog post.

Touch Infographic: From Touch Receptors to the Brain
The body contains thousands of receptors and nerves which allow us to experience the sense of touch, also referred to as tactile perception. The somatosensory system allows organisms to perceive and decode a wide range of tactile stimuli to allow for...  Read full blog post.

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Bioinformatics

Gene Symbol TRPA1
Entrez
Uniprot