Troponin I Type 3 (cardiac) Antibody (12G3)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, IP
Clone
12G3
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

Troponin I Type 3 (cardiac) Antibody (12G3) Summary

Immunogen
Human cardiac troponin C.
Specificity
cardiac Troponin C (12G3)
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
TNNI3
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunoprecipitation 1:10-1:500

Reactivity Notes

Cross-reacts with Human.Not yet tested in other species.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS (pH 7.4)
Preservative
0.09% Sodium Azide
Purity
Protein A purified

Alternate Names for Troponin I Type 3 (cardiac) Antibody (12G3)

  • Cardiac troponin I
  • CMD1FF
  • CMD2A
  • CMH7MGC116817
  • cTnI
  • familial hypertrophic cardiomyopathy 7
  • RCM1
  • TNNC1troponin I, cardiac
  • troponin I type 3 (cardiac)
  • troponin I, cardiac muscle

Background

Troponin (Tn) is the central regulatory protein of striated muscle contraction. Tn consists of three components: TnI which is the inhibitor of actomyosin ATPase, TnT which contains the binding site for tropomyosin and TnC. The binding of calcium to TnC abolishes the inhibitory action of Tn on actin filaments, and as a result of calcium ion uptake by troponin C, the elements of the muscle thin filament undergo a series of allosteric changes which allow the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Troponin I Type 3 (cardiac) Antibody (NB110-8463) (0)

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

Additional Troponin I Type 3 (cardiac) Products

Bioinformatics Tool for Troponin I Type 3 (cardiac) Antibody (NB110-8463)

Discover related pathways, diseases and genes to Troponin I Type 3 (cardiac) Antibody (NB110-8463). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Blogs on Troponin I Type 3 (cardiac).

Troponin I Type 3 (TnI, cardiac)
Troponin I is part of a heteromeric thin filament regulatory complex that governs skeletal and cardiac muscle contraction. Troponin I is composed of three subunits: troponin I (TnI), troponin T (TnT), and troponin C (TnC), and each of these components...  Read full blog post.

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Bioinformatics

Gene Symbol TNNI3
Entrez