TrkC Antibody

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Immunocytochemistry/ Immunofluorescence: TrkC Antibody [NB100-98828] - Rat DRG (postnatal day 7) at 40 ug/ml concentration using Sheep antibody to extracellular domain of TrkC (Trk-C, NTRK3, NT-3 growth factor ...read more
Immunohistochemistry-Paraffin: TrkC Antibody [NB100-98828] - IHC on paraffin sections of rat DRG using Rabbit antibody to TrkC.HIER: 1 mM EDTA, pH 8 for 20 min. Blocking: 0.2% LFDM in TBST filtered thru 0.2 um.Detection ...read more
Immunocytochemistry/ Immunofluorescence: TrkC Antibody [NB100-98828] - IF on rat DRG (postnatal day 7) at 40 ug/ml concentration using Sheep antibody to extracellular domain of rat, mouse, human, monkey TrkC (Trk-C, ...read more
Immunocytochemistry/ Immunofluorescence: TrkC Antibody [NB100-98828] - IF on rat DRG (postnatal day 7) at 40 ug/ml concentration using Sheep antibody to extracellular domain of rat, mouse, human, monkey TrkC (Trk-C, ...read more
Immunohistochemistry-Paraffin: TrkC Antibody [NB100-98828] - IHC on paraffin sections of rat DRG using Rabbit antibody to TrkC.HIER: 1 mM EDTA, pH 8 for 20 min. Blocking: 0.2% LFDM in TBST filtered thru 0.2 um. ...read more

Product Details

Summary
Product Discontinued
View other related TrkC Primary Antibodies

Order Details


    • Catalog Number
      NB100-98828
    • Availability
      Product Discontinued

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TrkC Antibody Summary

Immunogen
A synthetic peptide from the extracellular domain of rat, mouse, human, monkey TrkC conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity
TrkC.
Clonality
Polyclonal
Host
Sheep
Gene
NTRK3
Purity
IgG purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 10-50 ug/ml
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500

Reactivity Notes

Rat and Mouse.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
No Preservative
Concentration
LYOPH
Purity
IgG purified
Reconstitution Instructions
Reconstitute with 0.5 ml sterilized water. Add glycerol (1:1) for additional stability.

Alternate Names for TrkC Antibody

  • EC 2.7.10
  • EC 2.7.10.1
  • ETS related protein-neurotrophic receptor tyrosine kinase fusion protein
  • ETV6-NTRK3 fusion
  • gp145(trkC)
  • GP145-TrkC
  • Neurotrophic tyrosine kinase receptor type 3
  • neurotrophic tyrosine kinase, receptor, type 3
  • NT 3 receptor
  • NT-3 growth factor receptor
  • NTRK3
  • TrkC tyrosine kinase
  • TrkC
  • trk-C
  • TRKCneurotrophin 3 receptor
  • tyrosine kinase receptor C

Background

FUNCTION: Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.; SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and ARMS. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

Additional TrkC Products

Bioinformatics Tool for TrkC Antibody (NB100-98828)

Discover related pathways, diseases and genes to TrkC Antibody (NB100-98828). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for TrkC Antibody (NB100-98828)

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Pathways for TrkC Antibody (NB100-98828)

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PTMs for TrkC Antibody (NB100-98828)

Learn more about PTMs related to TrkC Antibody (NB100-98828).

Blogs on TrkC.

TrkB: Bridging Ontogenesis and Oncogenesis
Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. Interaction of brain-derived neurotrophic factor (BDNF) with its...  Read full blog post.

TrkB: Docking for Neurotrophins and Beyond.
Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. TrK's are activated by several neurotrophins, which are small pro...  Read full blog post.

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Bioinformatics

Gene Symbol NTRK3
Entrez
Uniprot