TRIM5 alpha Antibody

Images

 
Western Blot: TRIM5 alpha Antibody [NBP1-47111] - analysis of TRIM5a expression in human stomach (A), thymus (B), and uterus (C) cell lysate with anti-TRIM5a at 2 ug /ml.
Immunocytochemistry/ Immunofluorescence: TRIM5 alpha Antibody [NBP1-47111] - of TRIM5a in human breast tissue with anti-TRIM5a at 10 ug/ml.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-47111
    • Availability
      Product Discontinued

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TRIM5 alpha Antibody Summary

Immunogen
Rabbit anti-TRIM5a polyclonal antibody was raised against a synthetic peptide corresponding to amino acids near the C-terminus of rhesus monkey TRIM5a (Genbank accession No. AAS48505).
Clonality
Polyclonal
Host
Rabbit
Gene
TRIM5
Purity
IgG purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 1:10-1:2000

Reactivity Notes

human

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS
Preservative
0.02% Sodium Azide
Purity
IgG purified

Alternate Names for TRIM5 alpha Antibody

  • EC 6.3.2
  • EC 6.3.2.-
  • RING finger protein 88
  • RNF88tripartite motif protein TRIM
  • TRIM5alpha
  • tripartite motif containing 5
  • tripartite motif protein TRIM5
  • tripartite motif-containing 5
  • tripartite motif-containing protein 5

Background

TRIM5-alpha is a protein that is found in the cells of many mammals and fends of various retrovirus infections. It protects monkeys from infection with HIV-1, and humans from infection with some other viruses. If a retrovirus has entered a cell, it needs to shed its capsid in order to reversely transcribe its genes, so that they can be expressed by the host cell. It is believed that TRIM5 alpha, which is present in the cytoplasm, somehow recognizes the capsid and blocks its shedding, thereby stopping the virus in its tracks. It thus represents an intracellular defense completely separate from the rest of the body's immune system.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Contact Information

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Bioinformatics

Gene Symbol TRIM5