TRIAD3A Antibody

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Western Blot: TRIAD3A Antibody [NB100-56891] - Analysis of TRIAD3A in human (A)Brain; (B) Heart; (C) Small Intestine; (D) Kidney; (E) Liver; (F) Lung; (G) Skeletal Muscle; (H) Pancreas; (I) Spleen; (J) Ovary; (K) Testis ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

TRIAD3A Antibody Summary

Immunogen
This antibody was developed against KLH-conjugated synthetic peptide corresponding to a portion of human TRIAD3 between amino acids 350-400.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
RNF216
Purity
Protein G purified
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Applications/Dilutions

Reactivity Notes

Cross reacts with Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS containing 0.2% gelatin
Preservative
0.05% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein G purified

Alternate Names for TRIAD3A Antibody

  • EC 6.3.2.-
  • ring finger protein 216Ubiquitin-conjugating enzyme 7-interacting protein 1
  • Triad domain-containing protein 3
  • TRIAD3Zinc finger protein inhibiting NF-kappa-B
  • U7I1
  • UBCE7IP1ubiquitin conjugating enzyme 7 interacting protein 1
  • ZINE3 ubiquitin-protein ligase RNF216

Background

Official Gene Symbol: TRIAD3 Gene ID: 54476 (Human) Gene Map Locus: 7p22.1 (Human) TRIADs are novel zinc finger proteins characterized by the presence of Cysteine rich TRIAD domain consisting of DRIL motif flanked by 2 RING fingers. TRIAD3, a 56KDa protein, is a novel member of this family. It contains 4 RLD domains in the centre and a proline-rich domain at the C-terminus. Localized in the cytoplasm, it interacts with RIP and inhibits TNF and IL1-induced NF-kappaB activation pathways. Reports suggest TRIAD3 acts as an E3-ubiquitin-protein ligase and promotes ubiquitination and degradation of TLR4 and TLR9, thereby regulating TLR signaling. It also interacts with HIV type I Vif protein and interferes in the early events of HIV-1 replication.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol RNF216
Entrez
Uniprot