TREML1/TLT-1 Antibody (268529) [Alexa Fluor® 647]



Product Details

Product Discontinued
View other related TREML1/TLT-1 Primary Antibodies

Order Details

    • Catalog Number
    • Availability
      Product Discontinued

    Can't find what you are looking for? Use our Antibody Concierge Service & we will help you locate your antibody!

    Or feel free to contact us for alternative products.

TREML1/TLT-1 Antibody (268529) [Alexa Fluor® 647] Summary

Mouse myeloma cell line NS0-derived recombinant mouse TREML1/TLT‑1
Accession # NP_082039
Detects mouse TREML1/TLT‑1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human TREML1 is observed.
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

Store at 4C in the dark.
50mM Sodium Borate
0.05% Sodium Azide
Protein A or G purified from hybridoma culture supernatant


This product is provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for TREML1/TLT-1 Antibody (268529) [Alexa Fluor® 647]

  • dJ238O23.3
  • GLTL1825
  • PRO3438
  • TLT1
  • TLT-1
  • TLT1MGC119173
  • TREML1
  • trem-like transcript 1 protein
  • triggering receptor expressed on myeloid cells-like 1
  • Triggering receptor expressed on myeloid cells-like protein 1


Triggering receptor expressed on myeloid cells-like protein 1 (TREML1)/TREM-like transcript-1 (TLT1) is a 40 kDa type I transmembrane receptor and member of the TREM family of proteins (1). Mouse TREML1/TLT-1 is synthesized as a 317 amino acid (aa) precursor that contains a 20 aa signal sequence, a 155 aa extracellular domain (ECD), a 21 aa transmembrane region, and a 121 aa cytoplasmic domain. The ECD contains an Ig-like V-type domain (aa 21-122), and the cytoplasmic region contains a proline-rich region (aa 245-275) and an immunoreceptor tyrosine-based inhibition motif (ITIM) characterized by the residues S/I/V/LXYxxV/L (1). A splicing variant produces a second isoform that has a six aa substitution for aa 173 in isoform 1. Mature mouse TREML1/TLT-1 shares 65% aa sequence identity with mature human TREML1/TLT-1. TREML1/TLT-1 is expressed exclusively in megakaryocytes and platelets where it colocalizes with CD62P in granules in resting platelets and on the cell surface of platelets activated by thrombin (1-3). The receptor's expression is up-regulated dramatically upon platelet activation (2). Antibodies to single-chain Fv fragments specific for TLT-1 inhibited thrombin-mediated human platelet aggregation suggesting its role in the regulation of aggregation (5). In addition, soluble fragments including the ECD can be released into serum by proteolysis (3). The phosphorylated TREML1/TLT-1 is able to interact with both SHP-1 and SHP-2 through ITIM (1, 4). SHP-2 interaction enhances Fc-RI-mediated calcium signaling in rat basophilic leukemia cells (1). It is hypothesized that TREML1/TLT-1 plays a role in the innate and adaptive immune responses.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

Species: Hu
Applications: Flow, AgAct, CyTOF-ready
Species: Mu
Applications: WB, ICC
Species: Mu
Applications: WB, IHC, Block, ICC
Species: Hu, Rt, Hu(-)
Applications: WB, ICC/IF, IHC, IHC-P
Species: Hu, Mu, Rt, Po, Bv, Ch, Eq
Applications: WB, Simple Western, Flow, ICC/IF, IHC, IHC-Fr, IHC-P
Species: Hu
Applications: WB, CyTOF-ready, ICFlow
Species: Hu
Applications: WB, Simple Western, IHC
Species: Hu, Mu, Rt, Po, Bv, Pm
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P
Species: Mu
Applications: WB, Flow, CyTOF-ready
Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP
Species: Hu
Applications: WB, IHC, IHC-P
Species: Mu
Applications: Flow, CyTOF-ready, ICC
Species: Hu
Applications: Flow, CyTOF-ready, ICC
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IP
Species: Hu, Mu, Rt
Applications: WB, Simple Western, IHC, CyTOF-ready, ICFlow
Species: Mu
Applications: WB, IHC, Block
Species: Mu
Applications: WB

Publications for TREML1/TLT-1 Antibody (NBP2-48481AF647) (0)

There are no publications for TREML1/TLT-1 Antibody (NBP2-48481AF647).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for TREML1/TLT-1 Antibody (NBP2-48481AF647) (0)

There are no reviews for TREML1/TLT-1 Antibody (NBP2-48481AF647). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for TREML1/TLT-1 Antibody (NBP2-48481AF647) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies


Isotype Controls

Additional Array Products

Bioinformatics Tool for TREML1/TLT-1 Antibody (NBP2-48481AF647)

Discover related pathways, diseases and genes to TREML1/TLT-1 Antibody (NBP2-48481AF647). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for TREML1/TLT-1 Antibody (NBP2-48481AF647)

Discover more about diseases related to TREML1/TLT-1 Antibody (NBP2-48481AF647).

Pathways for TREML1/TLT-1 Antibody (NBP2-48481AF647)

View related products by pathway.

PTMs for TREML1/TLT-1 Antibody (NBP2-48481AF647)

Learn more about PTMs related to TREML1/TLT-1 Antibody (NBP2-48481AF647).

Blogs on TREML1/TLT-1

There are no specific blogs for TREML1/TLT-1, but you can read our latest blog posts.

Contact Information

Product PDFs


Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.


Review this Product

Be the first to review our TREML1/TLT-1 Antibody (268529) [Alexa Fluor® 647] and receive a gift card or discount.


Gene Symbol TREML1